AIFM2 blocking peptide

AIFM2 Antibody (C-term) Blocking Peptide

• Gene Names: AIFM2; AMID; PRG3
• Synonyms: AIFM2; AIFM2 Antibody (C-term) Blocking Peptide; Apoptosis-inducing factor 2; 1---; Apoptosis-inducing factor homologous mitochondrion-associated inducer of death; Apoptosis-inducing factor-like mitochondrion-associated inducer of death; p53-responsive gene 3 protein; AMID; PRG3; AIFM2 blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human AIFM2. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 373

• Cellular Location: Cytoplasm. Mitochondrion outer membrane.
• Tissue Location: Detected in most normal tissues as two transcripts of 1.8 and 4.0 kb in length, respectively. Highly expressed in heart, moderately in liver and skeletal muscles, and expressed at low levels in placenta, lung, kidney, and pancreas Both transcripts expressed following p53/TP53 induction. The shorter 1.8 kb transcript seems to be the major transcript in EB1 colon cancer cells.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AIFM2 blocking peptide

Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest.

NCBI and Uniprot Product Information

• NCBI GI #: 74752283
• NCBI GeneID: 84883
• UniProt Accession #: Q9BRQ8; Q63Z39; B3KXI0
• Molecular Weight: 36,520 Da
• NCBI Official Full Name: Apoptosis-inducing factor 2
• NCBI Official Synonym Full Names: apoptosis inducing factor, mitochondria associated 2
• NCBI Official Symbol: AIFM2
• NCBI Official Synonym Symbols: AMID; PRG3
• NCBI Protein Information: apoptosis-inducing factor 2
• UniProt Protein Name: Apoptosis-inducing factor 2
• Protein Family: Apoptosis-inducing factor
• UniProt Gene Name: AIFM2
• UniProt Entry Name: AIFM2_HUMAN

NCBI Description

This gene encodes a flavoprotein oxidoreductase that binds single stranded DNA and is thought to contribute to apoptosis in the presence of bacterial and viral DNA. The expression of this gene is also found to be induced by tumor suppressor protein p53 in colon cancer cells. [provided by RefSeq, Nov 2010]

Uniprot Description

AIFM2: Oxidoreductase, which may play a role in mediating a p53/TP53-dependent apoptosis response. Probable oxidoreductase that acts as a caspase-independent mitochondrial effector of apoptotic cell death. Binds to DNA in a sequence-independent manner. May contribute to genotoxin-induced growth arrest. Belongs to the FAD-dependent oxidoreductase family. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Oxidoreductase; Apoptosis; EC 1.-.-.-; Mitochondrial

Chromosomal Location of Human Ortholog: 10q22.1

Cellular Component: cytoplasm; cytosol; extracellular space; lipid particle; mitochondrial outer membrane; mitochondrion

Molecular Function: DNA binding; electron-transferring-flavoprotein dehydrogenase activity; FAD binding

Biological Process: apoptotic mitochondrial changes; positive regulation of apoptosis; regulation of apoptosis