ADCY7 blocking peptide

ADCY7 Antibody (Center) Blocking Peptide

• Gene Names: ADCY7; AC7
• Synonyms: ADCY7; ADCY7 Antibody (Center) Blocking Peptide; Adenylate cyclase type 7; ATP pyrophosphate-lyase 7; Adenylate cyclase type VII; Adenylyl cyclase 7; KIAA0037; ADCY7 blocking peptide

• Form/Format: Lyophilized with 100% acetonitrile and is supplied as a powder.
• Sequence Length: 1080

• Reconstitution: Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for ADCY7 blocking peptide

ADCY7 encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences.

NCBI and Uniprot Product Information

• NCBI GI #: 4557255
• NCBI GeneID: 113
• NCBI Accession #: NP_001105.1
• NCBI GenBank Nucleotide #: NM_001114.4
• UniProt Accession #: P51828
• NCBI Official Full Name: adenylate cyclase type 7 isoform 1
• NCBI Official Synonym Full Names: adenylate cyclase 7
• NCBI Official Symbol: ADCY7
• NCBI Official Synonym Symbols: AC7
• NCBI Protein Information: adenylate cyclase type 7
• UniProt Protein Name: Adenylate cyclase type 7
• Protein Family: Adenylate cyclase
• UniProt Gene Name: ADCY7

NCBI Description

This gene encodes a membrane-bound adenylate cyclase that catalyses the formation of cyclic AMP from ATP and is inhibitable by calcium. The product of this gene is a member of the adenylyl cyclase class-4/guanylyl cyclase enzyme family that is characterized by the presence of twelve membrane-spanning domains in its sequences. Several transcript variants have been observed for this gene, but the full-length natures of only two have been determined so far. [provided by RefSeq, Oct 2013]

Uniprot Description

Catalyzes the formation of cAMP in response to activation of G protein-coupled receptors (Probable). Functions in signaling cascades activated namely by thrombin and sphingosine 1-phosphate and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G alpha protein with GNA13 (PubMed:23229509, PubMed:18541530). Also, during inflammation, mediates zymosan-induced increase intracellular cAMP, leading to protein kinase A pathway activation in order to modulate innate immune responses through heterotrimeric G proteins G(12/13) (). Functions in signaling cascades activated namely by dopamine and C5 alpha chain and mediates regulation of cAMP synthesis through synergistic action of the stimulatory G protein with G beta:gamma complex (PubMed:23842570, PubMed:23229509). Functions, through cAMP response regulation, to keep inflammation under control during bacterial infection by sensing the presence of serum factors, such as the bioactive lysophospholipid (LPA) that regulate LPS-induced TNF-alpha production. However, it is also required for the optimal functions of B and T cells during adaptive immune responses by regulating cAMP synthesis in both B and T cells ().