AADAC blocking peptide

AADAC Antibody (C-term) Blocking Peptide

• Gene Names: AADAC; DAC; CES5A1
• Synonyms: AADAC; AADAC Antibody (C-term) Blocking Peptide; Arylacetamide deacetylase; DAC; AADAC blocking peptide

• Specificity: The synthetic peptide sequence used to generate the antibody was selected from the C-term region of human AADAC. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
• Sequence Length: 399

• Cellular Location: Endoplasmic reticulum membrane; Single-pass type II membrane protein. Microsome membrane; Single-pass type II membrane protein
• Tissue Location: Detected in liver (at protein level). Mainly expressed in liver, small intestine, colon, adrenal gland and bladder.
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for AADAC blocking peptide

Displays cellular triglyceride lipase activity in liver, increases the levels of intracellular fatty acids derived from the hydrolysis of newly formed triglyceride stores and plays a role in very low-density lipoprotein assembly. Displays serine esterase activity in liver. Deacetylates a variety of arylacetamide substrates, including xenobiotic compounds and procarcinogens, converting them to the primary arylamide compounds and increasing their toxicity.

NCBI and Uniprot Product Information

• NCBI GI #: 317373587
• NCBI GeneID: 13
• UniProt Accession #: P22760; Q8N1A9; A8K3L3; D3DNJ6
• Molecular Weight: 45,734 Da
• NCBI Official Full Name: Arylacetamide deacetylase
• NCBI Official Synonym Full Names: arylacetamide deacetylase
• NCBI Official Symbol: AADAC
• NCBI Official Synonym Symbols: DAC; CES5A1
• NCBI Protein Information: arylacetamide deacetylase
• UniProt Protein Name: Arylacetamide deacetylase
• Protein Family: Arylacetamide deacetylase
• UniProt Gene Name: AADAC
• UniProt Synonym Gene Names: DAC
• UniProt Entry Name: AAAD_HUMAN

NCBI Description

Microsomal arylacetamide deacetylase competes against the activity of cytosolic arylamine N-acetyltransferase, which catalyzes one of the initial biotransformation pathways for arylamine and heterocyclic amine carcinogens [provided by RefSeq, Jul 2008]

Uniprot Description

AADAC: Arylacetamide deacetylation is an important enzyme activity in the metabolic activation of arylamine substrates to ultimate carcinogens. Displays major serine hydrolase activity in liver microsomes. Hydrolyzes also flutamide, which is an antiandrogen drug used for the treatment of prostate cancer that occasionaly causes severe hepatotoxicity. Displays cellular triglyceride lipase activity in liver. Increases intracellular fatty acids derived from hydrolysis of newly formed triglyceride stores. Belongs to the 'GDXG' lipolytic enzyme family.

Protein type: Deacetylase; Endoplasmic reticulum; Motility/polarity/chemotaxis; Lipase; Membrane protein, integral; EC 3.1.1.3

Chromosomal Location of Human Ortholog: 3q25.1

Cellular Component: endoplasmic reticulum membrane

Molecular Function: catalytic activity; deacetylase activity; lipase activity; serine hydrolase activity; triacylglycerol lipase activity

Biological Process: xenobiotic metabolic process