5HT1A Receptor Blocking Peptide | HTR1A blocking peptide

5HT1A Receptor Blocking Peptide

Cat. Num. AAA9617156

• Gene Names: HTR1A; G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
• Applications: Blocking/Control
• Purity: The purity is >90%,tested by HPLC and MS.
• Synonyms: 5HT1A Receptor; 5HT1A Receptor Blocking Peptide; 5 HT 1A; 5 HT receptor 1A; 5 HT1A; 5 HT1A receptor; 5 hydroxytryptamine (serotonin) receptor 1A; 5 hydroxytryptamine (serotonin) receptor 1A G protein coupled; 5 hydroxytryptamine receptor 1A; 5-HT-1A; 5-HT1A; 5-hydroxytryptamine receptor 1A; 5HT 1A; 5HT 1A receptor; 5HT receptor 1A; 5HT1a; 5HT1A_HUMAN; ADRB2RL1; ADRBRL1; G 21; G protein coupled receptor; G-21; Gpcr 18; Gpcr18; Guanine nucleotide binding regulatory protein-coupled receptor; Htr1a; PFMCD; Serotonin 1A receptor; Serotonin 5HT1A receptor; Serotonin receptor 1A; HTR1A blocking peptide

• Purity/Purification: The purity is >90%,tested by HPLC and MS.
• Form/Format: Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 10 mg/ml.

• Applicable Applications for HTR1A blocking peptide: Blocking/Control
• Notes: For phospho antibody, we provide phospho peptide (0.5mg) and non-phospho peptide (0.5mg)
• Preparation and Storage: Maintain refrigerated at 2-8 degree C for up to 6 months. For long term storage store at -20 degree C.

Related Product Information for HTR1A blocking peptide

Blocking peptides are peptides that bind specifically to the target antibody and block antibody binding. These peptide usually contains the epitope recognized by the antibody. Antibodies bound to the blocking peptide no longer bind to the epitope on the target protein. This mechanism is useful when non-specific binding is an issue, for example, in Western blotting (immunoblot) and immunohistochemistry (IHC). By comparing the staining from the blocked antibody versus the antibody alone, one can see which staining is specific; Specific binding will be absent from the western blot or immunostaining performed with the neutralized antibody.

NCBI and Uniprot Product Information

• NCBI GI #: 55956923
• NCBI GeneID: 3350
• NCBI Accession #: NP_000515.2
• NCBI GenBank Nucleotide #: NM_000524.3
• UniProt Accession #: P08908; Q6LAE7
• Molecular Weight: 46,107 Da
• NCBI Official Full Name: 5-hydroxytryptamine receptor 1A
• NCBI Official Synonym Full Names: 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled
• NCBI Official Symbol: HTR1A
• NCBI Official Synonym Symbols: G-21; 5HT1a; PFMCD; 5-HT1A; 5-HT-1A; ADRBRL1; ADRB2RL1
• NCBI Protein Information: 5-hydroxytryptamine receptor 1A; 5-HT1a receptor; guanine nucleotide-binding regulatory protein-coupled receptor
• UniProt Protein Name: 5-hydroxytryptamine receptor 1A
• Protein Family: 5-hydroxytryptamine receptor
• UniProt Gene Name: HTR1A
• UniProt Synonym Gene Names: ADRB2RL1; ADRBRL1; 5-HT-1A; 5-HT1A
• UniProt Entry Name: 5HT1A_HUMAN

NCBI Description

This gene encodes a G protein-coupled receptor for 5-hydroxytryptamine (serotonin), and belongs to the 5-hydroxytryptamine receptor subfamily. Serotonin has been implicated in a number of physiologic processes and pathologic conditions. Inactivation of this gene in mice results in behavior consistent with an increased anxiety and stress response. Mutation in the promoter of this gene has been associated with menstrual cycle-dependent periodic fevers. [provided by RefSeq, Jun 2012]

Uniprot Description

5-HT(1A): This is one of the several different receptors for 5- hydroxytryptamine (serotonin), a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. The activity of this receptor is mediated by G proteins that inhibit adenylate cyclase activity. Belongs to the G-protein coupled receptor 1 family. 5- hydroxytryptamine receptor subfamily. HTR1A sub-subfamily.

Protein type: GPCR, family 1; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integral

Chromosomal Location of Human Ortholog: 5q11.2-q13

Cellular Component: integral to plasma membrane; plasma membrane

Molecular Function: protein binding; serotonin receptor activity

Biological Process: vasoconstriction; G-protein coupled receptor protein signaling pathway; cell proliferation; behavioral fear response; serotonin receptor, adenylate cyclase inhibiting pathway; regulation of serotonin secretion; positive regulation of cell proliferation; regulation of dopamine metabolic process; regulation of hormone secretion; serotonin metabolic process; serotonin receptor signaling pathway; regulation of behavior

Disease: Periodic Fever, Menstrual Cycle-dependent