UNC0321 tri Biochemical

UNC0321 tri (trifluoroacetate salt)

Cat. Num. AAA848972

• Purity: >=95%
• Synonyms: UNC0321 tri; UNC0321 tri (trifluoroacetate salt); 7- (2- (2- (dimethylamino) ethoxy) ethoxy)-6-methoxy-2- (4-methyl-1; 4-diazepan-1-yl)-N- (1-methylpiperidin-4-yl) quinazolin-4-amine; tri (trifluoroacetate) salt; UNC0321 tri biochemical

• Purity/Purification: >=95%
• Form/Format: A solution in methyl acetate

• Molecular Formula: C??H??F?N?O?
• SMILES: CN1CCC (NC2=C3C=C (OC)C (OCCOCCN (C)C)=CC3=NC (N4CCN (C)CCC4)=N2)CC1.O=C (O)C (F)(F)F.O=C (O)C (F)(F)F.O=C (O)C (F)(F)F
• InChi: InChI=1S/C27H45N7O3.3C2HF3O2/c1-31 (2)15-16-36-17-18-37-25-20-23-22 (19-24 (25)35-5)26 (28-21-7-11-33 (4)12-8-21)30-27 (29-23)34-10-6-9-32 (3)13-14-34;3*3-2 (4,5)1 (6)7/h19-21H,6-18H2,1-5H3, (H,28,29,30);3* (H,6,7)
• InChi Key: FEROTKYRPUJIEB-UHFFFAOYSA-N
• Preparation and Storage: Store at -20 degree C; Shelf life: ~24 months

Structure

Related Product Information for UNC0321 tri biochemical

UNC0321 is an inhibitor of G9a histone methyltransferase (HMTase) with picomolar potency. It is a quinazoline analogue with a Morrison Ki of 63 pM. It inhibits G9a with an IC50 of 6 nM and 9 nM in chemiluminescence-based oxygen tunneling (CLOT) assays and enzyme-coupled SAH detection assays (ECSD). It inhibits GLP (G9a like protein) with an IC50 of 15 nM and 23 nM in these assays. It is inactive against SET7/9, SET8/PreSET7 and PRMT3 in ECSD assays.

Product Categories/Family for UNC0321 tri biochemical

Enzyme Inhibitors; Methyltransferase Inhibitors; Biochemicals; Biochemicals (A-Z); Cancer Research; Epigenetic Regulation; Protein Lysine Methyltransferases (PKMTs); PKMT Inhibitors; Epigenetics; Writer Enzymes; Protein Lysine Methyltransferases (PKMTs);