Structure
trans-ISRIB Biochemical
trans-ISRIB
Purity
>=98% by TLC
Synonyms
trans-ISRIB; N; N'-trans-1; 4-cyclohexanediylbis[2- (4-chlorophenoxy) acetamide]; ISRIB; trans-ISRIB biochemical
Purity/Purification
>=98% by TLC
Form/Format
White solid
Solubility
DMSO (~ 5 mg/ml)
Molecular Formula
C??H??Cl?N2?O?
CAS Number
1597403-47-8
PubChem CID
1011240
SMILES
C1CC (CCC1NC (=O)COC2=CC=C (C=C2)Cl)NC (=O)COC3=CC=C (C=C3)Cl
InChi
InChI=1S/C22H24Cl2N2O4/c23-15-1-9-19 (10-2-15)29-13-21 (27)25-17-5-7-18 (8-6-17)26-22 (28)14-30-20-11-3-16 (24)4-12-20/h1-4,9-12,17-18H,5-8,13-14H2, (H,25,27)(H,26,28)
InChi Key
HJGMCDHQPXTGAV-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Protect from air and light
Shelf life: ~36 months
Structure
Structure
Related Product Information for trans-ISRIB biochemical
trans-ISRIB is an integrated stress response inhibitor. Potently reverses the effects of initiation factor 2alpha (eIF2alpha) phosphorylation (IC50 = 5 nM). Enhances spatial and fear-associated learning in mice and enhances cognitive function. Mechanism of action involves activation of eiF2beta. Suppresses ER stress-induced inflammatory gene expression. Potently attenuates amyloid beta-induced neuronal cell death (12.5-25 nM) with no effect on amyloid beta production. Reverses hippocampal-dependent cognitive deficits induced by traumatic brain injury in two different injury mouse models.
Product Categories/Family for trans-ISRIB biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/1011240
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Product Notes
The trans-ISRIB (Catalog #AAA848204) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "trans-ISRIB, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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