Structure
FPS-ZM1 Biochemical
FPS-ZM1
Purity
>=98% by HPLC
Synonyms
FPS-ZM1; 4-Chloro-N-cyclohexyl-N- (phenylmethyl) benzamide; FPS-ZM1 biochemical
Purity/Purification
>=98% by HPLC
Form/Format
White solid
Solubility
DMSO (~ 30 mg/ml) or EtOH (~25 mg/ml)
Molecular Formula
C??H??ClNO
CAS Number
945714-67-0
PubChem CID
24752728
SMILES
C1CCC (CC1)N (CC2=CC=CC=C2)C (=O)C3=CC=C (C=C3)Cl
InChi
InChI=1S/C20H22ClNO/c21-18-13-11-17 (12-14-18)20 (23)22 (19-9-5-2-6-10-19)15-16-7-3-1-4-8-16/h1,3-4,7-8,11-14,19H,2,5-6,9-10,15H2
InChi Key
XDFKWGIBQMHSOH-UHFFFAOYSA-N
Preparation and Storage
Store at -20 degree C
Protect from air and light
Shelf life: ~36 months
Protect from air and light
Shelf life: ~36 months
Structure
Structure
Related Product Information for FPS-ZM1 biochemical
FPS-ZM1 is a high-affinity, brain-permeable, RAGE (Receptor for Advanced Glycation End products) receptor antagonist (Ki = 25 nM). It lowers levels of Abeta via binding to the V domain of RAGE and can block multiple mechanisms of Abeta40- and Abeta42-induced cellular stress in RAGE-expressing brain endothelium, neurons and microglia in vitro and in vivo. In a rat model of intracerebral hemorrhage, FPS-ZM1 attenuates blood-brain barrier and white matter fiber damage. It ameliorates inflammatory damage after acute intracerebral hemorrhage via downstream blockade of high mobility box-1 (HMGB1) signaling.
Product Categories/Family for FPS-ZM1 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/24752728
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Product Notes
The FPS-ZM1 (Catalog #AAA848231) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "FPS-ZM1, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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