Structure
Silvestrol Biochemical
Silvestrol
Purity
>98% (HPLC)
Synonyms
Silvestrol; (-)-Silvestrol; Silvestrol biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO
H2O: <1mg/mL
H2O: <1mg/mL
Target
Apoptosis
Receptor
Apoptosis
Chemical Name
1H-Cyclopenta[b]benzofuran-2-carboxylic acid, 6-[[(2S, 3R, 6R)-6-[(1R)-1, 2-dihydroxyethyl]-3-methoxy-1, 4-dioxan-2-yl]oxy]-2, 3, 3a, 8b-tetrahydro-1, 8b-dihydroxy-8-methoxy-3a-(4-methoxyphenyl)-3-phenyl-, methyl ester, (1R, 2R, 3S, 3aR, 8bS)
SMILES
O=C([C@H]([C@H]1C2=CC=CC=C2)[C@@H](O)[C@]3(O)[C@@]1(C4=CC=C(OC)C=C4)OC5=C3C(OC)=CC(OC6O[C@@H]([C@H](O)CO)CO[C@H]6OC)=C5)OC
Molecular Formula
C34H38O13
CAS Number
697235-38-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Silvestrol biochemical
Silvestrol is a potential anticancer rocaglate derivative from Aglaia foveolata, induces apoptosis in cancer cells through the mitochondrial/apoptosome pathway; effectively targets the cyclin/CDK/Rb pathway, and additionally induces cytotoxicity via intrinsic apoptosis, exhibits low nanomolar potency both in MCL cell lines and primary MCL tumor cells; demonstrates B-cell selective activity in chronic lymphocytic leukemia and acute lymphoblastic leukemia in vitro and in vivo.
References
1. Lucas DM, et al. Blood. 2009 May 7; 113 (19):4656-66.
2. Kim S, et al. Anticancer Res. 2007 Jul-Aug; 27 (4B):2175-83.
3. Hwang BY, et al. J Org Chem. 2004 May 14; 69 (10):3350-8.
4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1; 18 (17):4600-11.
2. Kim S, et al. Anticancer Res. 2007 Jul-Aug; 27 (4B):2175-83.
3. Hwang BY, et al. J Org Chem. 2004 May 14; 69 (10):3350-8.
4. Alinari L, et al. Clin Cancer Res. 2012 Sep 1; 18 (17):4600-11.
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Product Notes
The Silvestrol (Catalog #AAA3605671) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Silvestrol, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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