Structure
SG3199 Biochemical
SG3199
Purity
>98% (HPLC)
Synonyms
SG3199; SG-3199; SG 3199; SG3199 biochemical
Purity/Purification
>98% (HPLC)
Target
ADC Cytotoxin
Receptor
ADC Cytotoxin
Chemical Name
7-methoxy-8-((5-(((S)-7-methoxy-2-methyl-5-oxo-5, 11a-dihydro-1H-benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-8-yl)oxy)pentyl)oxy)-2-methyl-1, 11a-dihydro-5H-benzo[e]pyrrolo[1, 2-a][1, 4]diazepin-5-one
SMILES
O=C1C2=CC(OC)=C(OCCCCCOC3=C(OC)C=C4C(N=C[C@@](CC(C)=C5)([H])N5C4=O)=C3)C=C2N=C[C@@]6([H])N1C=C(C)C6
Molecular Formula
C33H36N4O6
CAS Number
1595275-71-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SG3199 biochemical
SG3199 (SG-3199) is a PBD dimer warhead component of antibody-drug conjugate (ADC) payload tesirine, demonstrates potently cytotoxic against a panel of human solid tumour and haematological cancer cell lines with mean GI50 of 151.5 pM; high-efficiently causes DNA interstrand cross-links in cancer cells; ADCT-402 (loncastuximab tesirine) is a novel CD19-targeted ADC delivering SG3199, ADCT-402 is highly potent, dose-dependent antitumor activity in several subcutaneous and disseminated human tumor models with marked superiority to comparator ADCs delivering tubulin inhibitors.
Product Categories/Family for SG3199 biochemical
References
1. Zammarchi F, et al. Blood. 2018 Mar 8; 131 (10):1094-1105.
2. Hartley JA, et al. Sci Rep. 2018 Jul 11; 8 (1):10479.
2. Hartley JA, et al. Sci Rep. 2018 Jul 11; 8 (1):10479.
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Product Notes
The SG3199 (Catalog #AAA3602278) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SG3199, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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