Structure
SB-649868 Biochemical
SB-649868
Purity
>98% (HPLC)
Synonyms
SB-649868; SB 649868; SB649868; SB-649868 biochemical
Purity/Purification
>98% (HPLC)
Target
Orexin Receptor
Receptor
Orexin Receptor
Chemical Name
(S)-N-((1-(5-(4-fluorophenyl)-2-methylthiazole-4-carbonyl)piperidin-2-yl)methyl)benzofuran-4-carboxamide
SMILES
O=C(C1=C2C=COC2=CC=C1)NC[C@H]3N(C(C4=C(C5=CC=C(F)C=C5)SC(C)=N4)=O)CCCC3
Molecular Formula
C26H24FN3O3S
CAS Number
380899-24-1
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SB-649868 biochemical
A potent, selective, orally bioavailable, dual orexin OX1/OX2R antagonist with pKi of 9.4 and 9.5 respectively; displays >1,000-fold selectivity for the orexin target receptors in a broad panel of GPCRs, ion channels and enzymes; demonstrates high effectivity in pre-clinical model of sleep disorders. Sleep Disorder Phase 2 Discontinued
Product Categories/Family for SB-649868 biochemical
References
1. Renzulli C, et al. Drug Metab Dispos. 2011 Feb; 39 (2):215-27.
2. Bettica P, et al.Neuropsychopharmacology. 2012 Apr; 37 (5):1224-33.
3. Piccoli L, et al. Neuropsychopharmacology. 2012 Aug; 37 (9):1999-2011.
4. Di Fabio R, et al. Bioorg Med Chem Lett. 2011 Sep 15; 21 (18):5562-7.
2. Bettica P, et al.Neuropsychopharmacology. 2012 Apr; 37 (5):1224-33.
3. Piccoli L, et al. Neuropsychopharmacology. 2012 Aug; 37 (9):1999-2011.
4. Di Fabio R, et al. Bioorg Med Chem Lett. 2011 Sep 15; 21 (18):5562-7.
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Product Notes
The SB-649868 (Catalog #AAA3604315) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SB-649868, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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