Structure
SAK3 Biochemical
SAK3
Purity
>98% (HPLC)
Synonyms
SAK3; T-VGCC enhancer SAK3; SAK3 biochemical
Purity/Purification
>98% (HPLC)
Target
Calcium Channel
Receptor
Calcium Channel
Chemical Name
Ethyl 8'-methyl-2', 4-dioxo-2-(piperidin-1-yl)-2'H-spiro[cyclopent[2]ene-1, 3'-imidazo[1, 2-a]pyridine]-3-carboxylate
SMILES
O=C(C1=C(N2CCCCC2)C3(N4C=CC=C(C)C4=NC3=O)CC1=O)OCC
Molecular Formula
C20H23N3O4
CAS Number
1256269-87-0
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for SAK3 biochemical
SAK3 (T-VGCC enhancer SAK3) is a potent, orally acitve enhancer of T-type voltage-gated Ca2+ channel (T-VGCC), enhances CaV3.1 and CaV3.3, but not CaV3.2 activity at concentrations of 0.01-10nM in neuro2A cells in vitro; significantly enhanced acetylcholine (ACh) release in the hippocampal CA1 region of nave mice (0.5mg/kg, p. O.); significantly enhanced hippocampal ACh levels in olfactory-bulbectomized (OBX) mice, rescuing impaired memory-related behaviors.
Product Categories/Family for SAK3 biochemical
References
1. Yabuki Y, et al. Neuropharmacology. 2017 May 1; 117:1-13.
2. Izumi H, et al. Neuroscience. 2018 May 1; 377:87-97.
3. Husain N, et al. Pharmacology. 2018; 101 (5-6):309-321.
4. Wang S, et al. PLoS One. 2018 Dec 20; 13 (12):e0206986.
2. Izumi H, et al. Neuroscience. 2018 May 1; 377:87-97.
3. Husain N, et al. Pharmacology. 2018; 101 (5-6):309-321.
4. Wang S, et al. PLoS One. 2018 Dec 20; 13 (12):e0206986.
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Product Notes
The SAK3 (Catalog #AAA3601047) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "SAK3, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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