Structure
RS-102895 Biochemical
RS-102895
Purity
>98% (HPLC)
Synonyms
RS-102895; RS102895; RS-102895 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Chemokine Receptor
Receptor
Chemokine Receptor
Chemical Name
Spiro[4H-3, 1-benzoxazine-4, 4'-piperidin]-2(1H)-one, 1'-[2-[4-(trifluoromethyl)phenyl]ethyl]
SMILES
C1CN(CCC12C3=CC=CC=C3NC(=O)O2)CCC4=CC=C(C=C4)C(F)(F)F.Cl
Molecular Formula
C21H21F3N2O2
CAS Number
300815-41-2
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for RS-102895 biochemical
A potent and specific CCR2 antagonist with binding IC50 of 360nM; shows no significant affinity on CXCR1, CCR1, or CCR3. (IC50>17uM); inhibits MCP-1-stimulated calcium influx into CCR2-CHL cells with IC50 of 32nM; significantly attenuates HG-induced ECM protein expression and TGF-beta1 levels in mouse mesangial cells (MCs).
Product Categories/Family for RS-102895 biochemical
References
1. Mirzadegan T, et al. J Biol Chem. 2000 Aug 18; 275 (33):25562-71.
2. Park J, et al. Am J Physiol Renal Physiol. 2008 Sep; 295 (3):F749-57.
3. Hung YW, et al. J Neuroinflammation. 2013 Jan 22; 10:11.
2. Park J, et al. Am J Physiol Renal Physiol. 2008 Sep; 295 (3):F749-57.
3. Hung YW, et al. J Neuroinflammation. 2013 Jan 22; 10:11.
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Product Notes
The RS-102895 (Catalog #AAA3603933) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "RS-102895, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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