Structure
PF-04929113 biochemical
PF-04929113
Purity
>=98% by HPLC
Synonyms
PF-04929113; PF04929113; glycine; trans-4-[[2-(aminocarbonyl)-5-[4; 5; 6; 7-tetrahydro-6; 6-dimethyl-4-oxo-3-(trifluoromethyl)-1H-indazol-1-yl]phenyl]amino]cyclohexyl ester; PF-04929113 biochemical
Specificity
A prodrug for the Hsp90 inhibitor; PF-04958473 (SNX-2112)
Purity/Purification
>=98% by HPLC
Form/Format
Crystalline solid
Solubilities
>50mg/ml DMSO
Molecular Formula
C??H??F?N?O?
InChi
InChI=1S/C25H30F3N5O4/c1-24(2)10-18-21(19(34)11-24)22(25(26; 27)28)32-33(18)14-5-8-16(23(30)36)17(9-14)31-13-3-6-15(7-4-13)37-20(35)12-29/h5; 8-9; 13; 15; 31H; 3-4; 6-7; 10-12; 29H2; 1-2H3; (H2; 30; 36)
InChi Key
AVDSOVJPJZVBTC-UHFFFAOYSA-N
SMILES
CC1(CC2=C(C(=O)C1)C(=NN2C3=CC(=C(C=C3)C(=O)N)NC4CCC(CC4)OC(=O)CN)C(F)(F)F)C
CAS Number
908115-27-5
PubChem CID
44195571
Preparation and Storage
Store at -20 degree C
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shipping: Gel Pack
Shelf Life: Est.~36 months
Country of Origin: USA
Do not take internally. Wear gloves and mask when handling the product! Avoid contact by all modes of exposure.
Shipping: Gel Pack
Shelf Life: Est.~36 months
Country of Origin: USA
Structure
Structure
Related Product Information for PF-04929113 biochemical
PF-04929113 is a prodrug for the Hsp90 inhibitor, PF-04958473 (SNX-2112). It binds both Hsp90alpha and Hsp90beta with an IC50 value of 30nM. PF-04929113, is rapidly absorbed and converted into the active inhibitor after oral administration. The active inhibitor causes degradation of Hsp90 client proteins, including HER2, and reduces phosphorylation of downstream kinases, including Akt and ERK1/2, leading to apoptosis in cancer cells.
Product Categories/Family for PF-04929113 biochemical
References
https://pubchem.ncbi.nlm.nih.gov/compound/44195571
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Product Notes
The PF-04929113 (Catalog #AAA8400402) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "PF-04929113, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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