Structure
NESS-0327 Biochemical
NESS-0327
Purity
>98% (HPLC)
Synonyms
NESS-0327; NESS 0327; NESS0327; NESS-0327 biochemical
Purity/Purification
>98% (HPLC)
Target
Cannabinoid Receptor
Receptor
Cannabinoid Receptor
Chemical Name
N-piperidinyl-[8-chloro-1-(2, 4-dichlorophenyl)-1, 4, 5, 6-tetrahydrobenzo[6, 7]cyclohepta[1, 2-c]pyrazole-3-carboxamide
SMILES
O=C(C1=NN(C2=CC=C(Cl)C=C2Cl)C3=C1CCCC4=CC(Cl)=CC=C43)NN5CCCCC5
Molecular Formula
C24H23Cl3N4O
CAS Number
494844-07-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for NESS-0327 biochemical
A potent, selective CB1 cannabinoid receptor antagonist with Ki of 350 fM, >60,000-fold selective for the CB1 receptor versus CB2 receptor (Ki=21nM); antagonizes WIN 55, 212-2-stimulated [35S]GTPgammaS binding, antagonizes the inhibitory effects of WIN 55, 212-2 on electrically evoked contractions in mouse isolated vas deferens preparations with pA2 12.46; inhibits the antinociceptive effect produced by WIN 55, 212-2 (2mg/kg s. C.) in both tail-flick (ID50=0.042mg/kg i. P.) and hot-plate test (ID50=0.018mg/kg i. P.).
Product Categories/Family for NESS-0327 biochemical
References
1. Ruiu S, et al. J Pharmacol Exp Ther. 2003 Jul; 306 (1):363-70.
2. Tambaro S, et al. Eur J Pharmacol. 2005 Nov 21; 525 (1-3):150-3.
3. Murineddu G, et al. J Med Chem. 2005 Nov 17; 48 (23):7351-62.
2. Tambaro S, et al. Eur J Pharmacol. 2005 Nov 21; 525 (1-3):150-3.
3. Murineddu G, et al. J Med Chem. 2005 Nov 17; 48 (23):7351-62.
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Product Notes
The NESS-0327 (Catalog #AAA3604655) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "NESS-0327, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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