Structure
Nalfurafine hydrochloride Biochemical
Nalfurafine hydrochloride
Purity
>98% (HPLC)
Synonyms
Nalfurafine hydrochloride; TRK-820 hydrochloride; Nalfurafine hydrochloride biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 21mg/mL
Target
Opioid Receptor
Receptor
kappa-opioidreceptor
Chemical Name
2-Propenamide, N-[(5alpha, 6beta)-17-(cyclopropylmethyl)-4, 5-epoxy-3, 14-dihydroxymorphinan-6-yl]-3-(3-furanyl)-N-methyl-, hydrochloride(1:1), (2E)
SMILES
CN(C1CCC2(C3CC4=C5C2(C1OC5=C(C=C4)O)CCN3CC6CC6)O)C(=O)C=CC7=COC=C7.Cl
Molecular Formula
C28H33ClN2O5
CAS Number
152658-17-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Nalfurafine hydrochloride biochemical
Nalfurafine (TRK-820, TRK820) is potent, selective agonist of kappa-opioid receptor with Ki of 3.5nM, 15-fold less potent for uOR and little affinity for deltaOR (Ki=53 and 1, 200nM, respectively); also potently binds to mutant kappa (E297K), u (K303E), kappa (E297W) and kappa (E297A) with Ki of 10-50nM; inhibits forskolin-stimulated intracellular cAMP accumulation with IC50 of 0.15nM, which is 100 fold smaller than that of U69593; produces potent antinociceptive effects in vivo. Other Indication Approved
Product Categories/Family for Nalfurafine hydrochloride biochemical
References
1. Nagase H, et al. Chem Pharm Bull (Tokyo). 1998 Feb; 46 (2):366-9.
2. Seki T, et al. Eur J Pharmacol. 1999 Jul 2; 376 (1-2):159-67.
3. Endoh T, et al. Life Sci. 1999; 65 (16):1685-94.
4. Endoh T, et al. Eur J Pharmacol. 2000 Jan 10; 387 (2):133-40.
2. Seki T, et al. Eur J Pharmacol. 1999 Jul 2; 376 (1-2):159-67.
3. Endoh T, et al. Life Sci. 1999; 65 (16):1685-94.
4. Endoh T, et al. Eur J Pharmacol. 2000 Jan 10; 387 (2):133-40.
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Product Notes
The Nalfurafine hydrochloride (Catalog #AAA3602135) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Nalfurafine hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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