Structure
ADL5859 Biochemical
ADL5859
Purity
>98% (HPLC)
Synonyms
ADL5859; ADL-5859; ADL 5859; ADL5859 biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
Opioid Receptor
Receptor
delta-opioidreceptor; kappa-opioidreceptor; u-opioidreceptor
Chemical Name
Benzamide, N, N-diethyl-4-(5-hydroxyspiro[2H-1-benzopyran-2, 4'-piperidin]-4-yl)-, hydrochloride(1:1)
SMILES
CCN(CC)C(=O)C1=CC=C(C=C1)C2=CC3(CCNCC3)OC4=CC=CC(=C42)O.Cl
Molecular Formula
C24H29ClN2O3
CAS Number
850173-95-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for ADL5859 biochemical
ADL5859 is a potent, selective, orally bioavailable full agonist of delta opioid receptor with Ki of 0.84nM and EC50 of 20nM, exhibits >1,000-fold selectivity for delta over u and kappa opioid receptors in both receptor binding and in vitro bioassays; demonstrates analgesic and antidepressive effects in the rat and represent potential drug for chronic pain treatment, significantly reduces inflammatory and neuropathic pain, does not induce either hyperlocomotion or receptor internalization in vivo. Pain Phase 2 Discontinued
Product Categories/Family for ADL5859 biochemical
References
1. Le Bourdonnec B, et al. J Med Chem. 2008 Oct 9; 51 (19):5893-6.
2. Nozaki C, et al. J Pharmacol Exp Ther. 2012 Sep; 342 (3):799-807.
3. Huang P, et al. Eur J Pharmacol. 2016 Jun 15; 781:53-9.
2. Nozaki C, et al. J Pharmacol Exp Ther. 2012 Sep; 342 (3):799-807.
3. Huang P, et al. Eur J Pharmacol. 2016 Jun 15; 781:53-9.
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Product Notes
The ADL5859 (Catalog #AAA3606169) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "ADL5859, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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