Ivacaftor benzenesulfonate Biochemical

Ivacaftor benzenesulfonate

• Purity: >98% (HPLC)
• Synonyms: Ivacaftor benzenesulfonate; VX-770 benzenesulfonate; VX 770 benzenesulfonate; Ivacaftor benzenesulfonate biochemical

• Purity/Purification: >98% (HPLC)

• Suitability: 10mM in DMSO
• Target: CFTR
• Receptor: CFTR
• Chemical Name: 3-Quinolinecarboxamide, N-[2, 4-bis(1, 1-dimethylethyl)-5-hydroxyphenyl]-1, 4-dihydro-4-oxo-, benzenesulfonate(1:1)
• SMILES: CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C.C1=CC=C(C=C1)S(=O)(=O)O
• Molecular Formula: C30H34N2O6S
• CAS Number: 1134822-09-5
• Preparation and Storage: Store at -20 degree C; Stability: >=2 years; Shipping: Ice Pack

Structure

Related Product Information for Ivacaftor benzenesulfonate biochemical

Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100nM; increases CFTR channel open probability (Po) in both the F508del processing mutation and the G551D gating mutation in recombinant cells, increases the Po of G551D CFTR by 6-fold, the Po of F508del- and wild-type CFTR by 5-fold and 2-fold, respectively; also potentiates CFTR-mediated Cl secretion in primary cultures of G551D/F508del HBE and F508del HBE; demonstrates potential for treatment of cystic fibrosis with certain mutations in CFTR gene (primarily the G551D mutation).Fibrosis Approved

Product Categories/Family for Ivacaftor benzenesulfonate biochemical

Fibrosis; Apoptosis; Other Indications

References

1. Van Goor F, et al. Proc Natl Acad Sci U S A. 2009 Nov 3; 106 (44):18825-30.
2. Accurso FJ, et al. N Engl J Med. 2010 Nov 18; 363 (21):1991-2003.
3. Yu W, et al. J Biol Chem. 2011 Jul 15; 286 (28):24714-25.
4. Hadida S, et al. J Med Chem. 2014 Dec 11; 57 (23):9776-95.