Structure
H3B-8800 Biochemical
H3B-8800
Purity
>98% (HPLC)
Synonyms
H3B-8800; H3B8800; H3B-8800 biochemical
Purity/Purification
>98% (HPLC)
Target
Spliceosome
Receptor
Spliceosome
Chemical Name
(2S, 3S, 6S, 7R, 10R, E)-7, 10-dihydroxy-3, 7-dimethyl-12-oxo-2-((R, 2E, 4E)-6-(pyridin-2-yl)hepta-2, 4-dien-2-yl)oxacyclododec-4-en-6-yl 4-methylpiperazine-1-carboxylate
SMILES
O=C(N1CCN(C)CC1)O[C@H]([C@](C)(O)CC[C@@H](O)C2)/C=C/[C@H](C)[C@@H](/C(C)=C/C=C/[C@H](C3=NC=CC=C3)C)OC2=O
Molecular Formula
C31H45N3O6
CAS Number
1825302-42-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for H3B-8800 biochemical
H3B-8800 is an orally available splicing modulator that targets spliceosome SF3b complex containing either WT or mutant SF3B1 (binding IC50 of 0.3-2nM); demonstrates dose-dependent inhibition of both canonical splicing and aberrant splicing induced by mutant SF3B1 in in vitro assays of biochemical splicing, induces lethality in spliceosome-mutant cancer cells. Blood Cancer Phase 1 Clinical
Product Categories/Family for H3B-8800 biochemical
References
1. Seiler M, et al. Nat Med. 2018 Feb 19. doi: 10.1038/nm.4493.
2. Finci LI, et al. Genes Dev. 2018 Feb 1; 32 (3-4):309-320.
3. Cancer Discov. 2018 Mar 2. doi: 10.1158/2159-8290.CD-RW2018-038.
2. Finci LI, et al. Genes Dev. 2018 Feb 1; 32 (3-4):309-320.
3. Cancer Discov. 2018 Mar 2. doi: 10.1158/2159-8290.CD-RW2018-038.
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Product Notes
The H3B-8800 (Catalog #AAA3602816) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "H3B-8800, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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