Structure
GS-5734 Biochemical
GS-5734
Purity
>98% (HPLC)
Synonyms
GS-5734; GS 5734; GS5734; Remdesivir; GS-5734 biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: >=125mg/mL (207.44mM)
Target
Filovirus
Receptor
Filovirus
Chemical Name
2-ethylbutyl((S)-(((2R, 3S, 4R, 5R)-5-(4-aminopyrrolo[1, 2-b]pyridazin-7-yl)-5-cyano-3, 4-dihydroxytetrahydrofuran-2-yl)methoxy)(phenoxy)phosphoryl)-L-alaninate
SMILES
CCC(CC)COC([C@H](C)N[P@](OC[C@H]1O[C@](C2=CC=C3N2N=CC=C3N)(C#N)[C@H](O)[C@@H]1O)(OC4=CC=CC=C4)=O)=O
Molecular Formula
C28H36N5O8P
CAS Number
1809249-37-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GS-5734 biochemical
GS-5734 (Remdesivir) is amonophosphoramidate prodrug of adenosine analogue that exhibits antiviral activity against multiple variants of EBOV (EC50=70-140nM) and other filoviruses (EC50=0.019-1.48uM) in cell-based assays; suppresses EBOV replication and protects 100% of EBOV-infected animals against lethal disease, ameliorating clinical disease signs and pathophysiological markers.Ebola Virus Infection Phase 2 Clinical
Product Categories/Family for GS-5734 biochemical
References
1. Warren TK, et al. Nature. 2016 Mar 17; 531 (7594):381-5.
2. Jacobs M, et al. Lancet. 2016 Jul 30; 388 (10043):498-503.
3. Siegel D, et al. J Med Chem. 2017 Mar 9; 60 (5):1648-1661.
2. Jacobs M, et al. Lancet. 2016 Jul 30; 388 (10043):498-503.
3. Siegel D, et al. J Med Chem. 2017 Mar 9; 60 (5):1648-1661.
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Product Notes
The GS-5734 (Catalog #AAA3602773) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GS-5734, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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