Structure
GR3027 Biochemical
GR3027
Purity
>98% (HPLC)
Synonyms
GR3027; GR-3027; Golexanolone; GR3027 biochemical
Purity/Purification
>98% (HPLC)
Target
GAT
Receptor
GAT
Chemical Name
(17E)-3alpha-ethynyl-17-(hydroxyimino)-5alpha-androstan-3beta-ol
SMILES
C[C@]1([C@](CC/2)([H])[C@]3([H])CC[C@@]4([H])C[C@](O)(C#C)CC[C@]4(C)[C@@]3([H])CC1)C2=NO
Molecular Formula
C21H31NO2
CAS Number
2089238-18-4
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for GR3027 biochemical
GR3027 (Golexanolone) is a GABA-A receptor modulating steroid antagonist that selectively antagonizes the enhanced activation of GABAA receptors by neurosteroids such as allopregnanolone and THDOC; inhibits alpha1beta2gamma2L receptor 29 +/- 5% of THDOC enhancement of the GABA response, does not antagonize the effect of GABA at the GABAA receptor; during the specific conditions used for the different receptors, IC50=250nM for the alpha1beta2gamma2L GABAA receptor and 350nM for the alpha5beta3gamma2L GABAA receptor; restores spatial learning and motor coordination in rats with chronic hyperammonemia and hepatic encephalopathy. Sleep Disorder Phase 2 Clinical
Product Categories/Family for GR3027 biochemical
References
1. Johansson M, et al. Am J Physiol Gastrointest Liver Physiol. 2015 Sep 1; 309 (5):G400-9.
2. Johansson M, et al. J Steroid Biochem Mol Biol. 2016 Jun; 160:98-105.
3. Johansson M, et al. Psychopharmacology (Berl). 2018 May; 235 (5):1533-1543.
4. Patent WO 2008/063128.
2. Johansson M, et al. J Steroid Biochem Mol Biol. 2016 Jun; 160:98-105.
3. Johansson M, et al. Psychopharmacology (Berl). 2018 May; 235 (5):1533-1543.
4. Patent WO 2008/063128.
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Product Notes
The GR3027 (Catalog #AAA3603263) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "GR3027, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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