Structure
Embelin Biochemical
Embelin
Purity
>98% (HPLC)
Synonyms
Embelin; Embelic acid; Emberine; NSC-91874; Embelin biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
IAP
Receptor
5-Lipoxygenase; mPGES-1; XIAP
Chemical Name
2, 5-Cyclohexadiene-1, 4-dione, 2, 5-dihydroxy-3-undecyl
SMILES
CCCCCCCCCCCC1=C(C(=O)C=C(C1=O)O)O
Molecular Formula
C17H26O4
CAS Number
550-24-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Embelin biochemical
Embelin (Embelic acid, Emberine, NSC-91874) is a cell-permeable benzoquinone compound that exhibits antitumor properties; specifically antagonizes XIAP-mediated inhibition of caspase-9 activation by directly targeting the Smac and caspase-9 binding domain BIR3 (IC50=4.1uM); has anti-inflammatory activities in both acute and chronic irritant contact dermatitis in vivo; also inhibits plasminogen activator inhibitor-1 (PAI-1) with IC50 of 1.62uM.
References
1. Siegel C, et al. Proc Natl Acad Sci U S A. 2011 Jul 12; 108 (28):11662-7.
2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15; 662 (1-3):63-9.
3. Lin Z, et al. Chem Biol. 2013 Feb 21; 20 (2):253-61.
2. Kalyan Kumar G, et al. Eur J Pharmacol. 2011 Jul 15; 662 (1-3):63-9.
3. Lin Z, et al. Chem Biol. 2013 Feb 21; 20 (2):253-61.
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Product Notes
The Embelin (Catalog #AAA3604987) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Embelin, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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