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Immunohistochemistry (IHC) (Anti-TFB2M antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Goat TFB2M Polyclonal Antibody | anti-TFB2M antibody

Goat Polyclonal to Human TFB2M

Gene Names
TFB2M; Hkp1; mtTFB2
Reactivity
Gibbon, Gorilla, Human
Applications
Immunohistochemistry, ELISA
Purity
Immunoaffinity Purified
Synonyms
TFB2M; Polyclonal Antibody; Goat Polyclonal to Human TFB2M; Anti-TFB2M Antibody (C-Terminus) IHC-plus; H-mtTFB; H-mtTFB2; HTFB2M; MtTFB2; Hkp1; NS5ATP5; Human TFB2M; anti-TFB2M antibody
Ordering
For Research Use Only!
Host
Goat
Reactivity
Gibbon, Gorilla, Human
Clonality
Polyclonal
Specificity
Human TFB2M.
Purity/Purification
Immunoaffinity Purified
Form/Format
Tris-buffered saline, pH 7.3, 0.5% BSA, 0.02% sodium azide
Sequence Length
396
Applicable Applications for anti-TFB2M antibody
Immunohistochemistry (IHC - Paraffin), ELISA (EIA)
Application Notes
ELISA (1:128000), IHC-P (5 ug/ml)
Target Species
Human
Immunogen Description
Synthetic peptide CAYKWLYDETLEDR from the C-terminus of human TFB2M (NP_071761.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%).
Immunogen Type
Synthetic peptide
Immunogen
TFB2M antibody was raised against synthetic peptide CAYKWLYDETLEDR from the C-terminus of human TFB2M (NP_071761.1). Percent identity by BLAST analysis: Human, Gorilla, Gibbon (100%).
Antigen Modification
C-Terminus
Preparation and Storage
Store at -20 degree C. Minimize freezing and thawing.

Immunohistochemistry (IHC)

(Anti-TFB2M antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

Immunohistochemistry (IHC) (Anti-TFB2M antibody IHC staining of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody concentration 5 ug/ml.)

NCBI and Uniprot Product Information

NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
45,349 Da
NCBI Official Full Name
dimethyladenosine transferase 2, mitochondrial
NCBI Official Synonym Full Names
transcription factor B2, mitochondrial
NCBI Official Symbol
TFB2M
NCBI Official Synonym Symbols
Hkp1; mtTFB2
NCBI Protein Information
dimethyladenosine transferase 2, mitochondrial; hTFB2M; h-mtTFB; h-mtTFB2; HCV NS5A-transactivated protein 5; mitochondrial 12S rRNA dimethylase 2; mitochondrial transcription factor B2; hepatitis C virus NS5A-transactivated protein 5; S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase 2
UniProt Protein Name
Dimethyladenosine transferase 2, mitochondrial
UniProt Gene Name
TFB2M
UniProt Synonym Gene Names
NS5ATP5; HCV NS5A-transactivated protein 5; h-mtTFB; h-mtTFB2; hTFB2M; mtTFB2
UniProt Entry Name
TFB2M_HUMAN

Uniprot Description

TFB2M: S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. Compared to TFB1M, it activates transcription of mitochondrial DNA more efficiently, while it has less methyltransferase activity. Belongs to the methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. KsgA subfamily.

Protein type: EC 2.1.1.-; Transcription, coactivator/corepressor; Methyltransferase

Chromosomal Location of Human Ortholog: 1q44

Cellular Component: mitochondrial matrix

Molecular Function: rRNA (adenine-N6,N6-)-dimethyltransferase activity; transcription cofactor activity

Biological Process: mitochondrion organization and biogenesis; organelle organization and biogenesis; positive regulation of transcription, DNA-dependent; rRNA methylation; gene expression; transcription initiation from mitochondrial promoter; transcription from mitochondrial promoter

Research Articles on TFB2M

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Product Notes

The TFB2M tfb2m (Catalog #AAA248529) is an Antibody produced from Goat and is intended for research purposes only. The product is available for immediate purchase. The Goat Polyclonal to Human TFB2M reacts with Gibbon, Gorilla, Human and may cross-react with other species as described in the data sheet. AAA Biotech's TFB2M can be used in a range of immunoassay formats including, but not limited to, Immunohistochemistry (IHC - Paraffin), ELISA (EIA). ELISA (1:128000), IHC-P (5 ug/ml). Researchers should empirically determine the suitability of the TFB2M tfb2m for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TFB2M, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.

Precautions

All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.

Disclaimer

Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.

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