Structure
Ladarixin sodium, Inhibitor
Ladarixin sodium
Purity
>98% (HPLC)
Synonyms
Ladarixin sodium; DF-2156; DF-2156A; inhibitor
Purity/Purification
>98% (HPLC)
Target
Chemokine Receptor
Receptor
Chemokine Receptor
Chemical Name
4-((2R)-1-Oxo-1-(methanesulfonamido)propan-2-yl)phenyl trifluoromethanesulfonate sodium salt
SMILES
CC(C1=CC=C(C=C1)OS(=O)(=O)C(F)(F)F)C(=O)[N-]S(=O)(=O)C.[Na+]
Molecular Formula
C11H11F3NNaO6S2
CAS Number
865625-56-5
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Ladarixin sodium, inhibitor
A novel allosteric, noncompetitive dual CXCR1/2 inhibitor that inhibits human polymorphonuclear leukocyte (PMN) migration to CXCL8 in vitro with IC50 of 0.7nM; prevents PMN infiltration and tissue damage in several models of IR injury in vivo; abrogates motility and induces apoptosis in cultured cutaneous and uveal melanoma cells and xenografts; also prevents inflammation-mediated damage in MLD-STZ, prevents and reverses diabetes in NOD mice. Diabetes Phase 2 Clinical
Product Categories/Family for Ladarixin sodium, inhibitor
References
1. Garau A, et al. Eur Cytokine Netw. 2006 Mar; 17 (1):35-41.
2. Citro A, et al. Diabetes. 2015 Apr; 64 (4):1329-40.
3. Kemp DM, et al. Oncotarget. 2017 Feb 28; 8 (9):14428-14442.
4. Bertini R, et al. Br J Pharmacol. 2012 Jan; 165 (2):436-54.
2. Citro A, et al. Diabetes. 2015 Apr; 64 (4):1329-40.
3. Kemp DM, et al. Oncotarget. 2017 Feb 28; 8 (9):14428-14442.
4. Bertini R, et al. Br J Pharmacol. 2012 Jan; 165 (2):436-54.
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Product Notes
The Ladarixin sodium (Catalog #AAA3606286) is an Inhibitor and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Ladarixin sodium, Inhibitor" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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