Structure
AM580 biochemical
AM580
Purity
>98%
Synonyms
AM580; 4-??[[(5; ??6; ??7; ??8-??tetrahydro-??5; ??5; ??8; ??8-??tetramethyl-??2-??naphthalenyl)?carbonyl]?amino]?-?benzoic acid; RO 40-6055; CD336; NSC 608001; AM580 biochemical
Purity/Purification
>98%
Form/Format
Appearance: White solid
CAS Number
102121-60-8
Structure Available?
Y
Salt Form
No
Cell-Permeable?
Yes
MDL Number
MFCD00673916
PubChem CID
2126
Solubility/Reconstitution Instructions
DMSO (~ 15 mg/ml)
SMILES
CC1(CCC(C2=C1C=CC(=C2)C(=O)NC3=CC=C(C=C3)C(=O)O)(C)C)C
InChi
nChI=1S/C22H25NO3/c1-21(2)11-12-22(3,4)18-13-15(7-10-17(18)21)19(24)23-16-8-5-14(6-9-16)20(25)26/h5-10,13H,11-12H2,1-4H3,(H,23,24)(H,25,26)
InChi Key
SZWKGOZKRMMLAJ-UHFFFAOYSA-N
Handling
Protect from air and light
Preparation and Storage
At -20 degree C
Shelf Life: 36 months
Shelf Life: 36 months
Structure
Structure
Related Product Information for AM580 biochemical
Background: AM580 is an analog of Retinoic acid that acts as aretinoic acid receptor agonist that is selective for RARalpha (Kd = 8 nM; AC?? = 0.36 nM) compared to RARbeta (Kd = 131 nM; AC?? = 24.6 nM) and RARgamma (Kd = 450 nM; AC?? = 27.9 nM). It displays greater specific binding to RARalpha compared to retinoic acid which exhibits little selectivity across RARalpha, beta, or gamma. AM580 has been used in combination with the GSK3beta inhibitor CHIR99021 to efficiently induce differentiation of human induced pluripotent stem cells into immediate mesoderm.
Product Categories/Family for AM580 biochemical
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Product Notes
The AM580 (Catalog #AAA842085) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "AM580, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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