Structure
Cinacalcet hydrochloride Biochemical
Cinacalcet hydrochloride
Purity
>98% (HPLC)
Synonyms
Cinacalcet hydrochloride; AMG 073 hydrochloride; AMG073 hydrochloride; AMG-073 hydrochloride; Cinacalcet; Cinacalcet hydrochloride biochemical
Purity/Purification
>98% (HPLC)
Suitability
10mM in DMSO
Target
CaSR
Receptor
CaSR
Chemical Name
1-Naphthalenemethanamine,.alpha.-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-, hydrochloride(1:1), (.alpha.R)
SMILES
C[C@H](C1=CC=CC2=CC=CC=C21)NCCCC3=CC(=CC=C3)C(F)(F)F.Cl
Molecular Formula
C22H23ClF3N
CAS Number
364782-34-3
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Structure
Structure
Related Product Information for Cinacalcet hydrochloride biochemical
A calcimimetic agent that acts as an allosteric activator of CaSR; increases the concentration of cytoplasmic Ca (2+) in human embryonic kidney 293 cells expressing the human parathyroid CaR with EC50 of 51nM; decreases PTH secretion from cultured bovine parathyroid cells with IC50 of 28nM; is used for the treatment of tertiary hyperparathyroidism. Hyperparathyroidism Approved
Product Categories/Family for Cinacalcet hydrochloride biochemical
References
1. Nemeth EF, et al. J Pharmacol Exp Ther. 2004 Feb; 308 (2):627-35.
2. Lindberg JS, et al. Kidney Int. 2003 Jan; 63 (1):248-54.
3. Quarles LD, et al. J Am Soc Nephrol. 2003 Mar; 14 (3):575-83.
2. Lindberg JS, et al. Kidney Int. 2003 Jan; 63 (1):248-54.
3. Quarles LD, et al. J Am Soc Nephrol. 2003 Mar; 14 (3):575-83.
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Product Notes
The Cinacalcet hydrochloride (Catalog #AAA3604253) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "Cinacalcet hydrochloride, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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