4-Hydroxyphenylpyruvic acid Biochemical
4-Hydroxyphenylpyruvic acid
Purity
>98% (HPLC)
Synonyms
4-Hydroxyphenylpyruvic acid; 4-Hydroxyphenylpyruvic acid biochemical
Purity/Purification
>98% (HPLC)
Suitability
DMSO: 10mM
Target
Endogenous Metabolite
Receptor
Human Endogenous Metabolite
SMILES
OC(=O)C(=O)Cc1ccc(O)cc1
Molecular Formula
C9H8O4
CAS Number
156-39-8
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Stability: >=2 years
Shipping: Ice Pack
Related Product Information for 4-Hydroxyphenylpyruvic acid biochemical
4-Hydroxyphenylpyruvic acid is an enzyme inhibitor.4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. Additionally 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction that converts 4-hydroxyphenylpyruvic acid to homogentisic acid. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine. It has been shown that hawkinsinuria an autosomal dominant disorder characterized by the excretion of 'hawkinsin' may also be a result of HPD deficiency. Moreover 4-hydroxyphenylpyruvic acid is also found to be associated in phenylketonuria which is also an inborn error of metabolism. There are two isomers of HPPA specifically 4HPPA and 3HPPA of which 4HPPA is the most common.
Product Categories/Family for 4-Hydroxyphenylpyruvic acid biochemical
References
1.Tomoeda K Awata H Matsuura T et al. Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria. [J]. Molecular Genetics & Metabolism 2000 71 (3):506-510.
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Product Notes
The 4-Hydroxyphenylpyruvic acid (Catalog #AAA3609681) is a Biochemical and is intended for research purposes only. The product is available for immediate purchase. It is sometimes possible for the material contained within the vial of "4-Hydroxyphenylpyruvic acid, Biochemical" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
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