4-Hydroxyphenylpyruvic acid, Inhibitor

4-Hydroxyphenylpyruvic acid

Cat. Num. AAA5751337

• Purity: 97.45%
• Synonyms: 4-Hydroxyphenylpyruvic acid; inhibitor

• Purity/Purification: 97.45%
• Form/Format: Powder

• Formula: C9H8O4
• CAS: 156-39-8
• Smiles: OC(=O)C(=O)Cc1ccc(O)cc1
• Receptor (IC50): Human Endogenous Metabolite
• Solubility: Water: Soluble; ethanol: 50mg/mL; (<1mg/ml refers to the product slightly soluble or insoluble)
• Preparation and Storage: Store at -20 degree C for 3 years powder; -80 degree C for 2 years in solvent; For obtaining a higher solubility, please warm the tube at 37 degree C and shake it in the ultrasonic bath for a while. Stock solution can be stored below -20 degree C for several month.

Structure

Related Product Information for 4-Hydroxyphenylpyruvic acid, inhibitor

4-Hydroxyphenylpyruvic acid is an enzyme inhibitor.4-Hydroxyphenylpyruvic acid (4-HPPA) is a keto acid that is involved in the tyrosine catabolism pathway. It is a product of the enzyme (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) and is formed during tyrosine metabolism. The conversion from tyrosine to 4-HPPA is catalyzed by tyrosine aminotransferase. Additionally, 4-HPPA can be converted to homogentisic acid which is one of the precursors to ochronotic pigment. The enzyme 4-hydroxyphenylpyruvic acid dioxygenase (HPD) catalyzes the reaction that converts 4-hydroxyphenylpyruvic acid to homogentisic acid. A deficiency in the catalytic activity of HPD is known to lead to tyrosinemia type III, an autosomal recessive disorder characterized by elevated levels of blood tyrosine and massive excretion of tyrosine derivatives into urine. It has been shown that hawkinsinuria, an autosomal dominant disorder characterized by the excretion of 'hawkinsin,' may also be a result of HPD deficiency. Moreover, 4-hydroxyphenylpyruvic acid is also found to be associated in phenylketonuria, which is also an inborn error of metabolism. There are two isomers of HPPA, specifically 4HPPA and 3HPPA, of which 4HPPA is the most common.

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References

1. Tomoeda K, Awata H, Matsuura T, et al. Mutations in the 4-hydroxyphenylpyruvic acid dioxygenase gene are responsible for tyrosinemia type III and hawkinsinuria.[J]. Molecular Genetics & Metabolism, 2000, 71 (3):506-510.
2. Guneral F,, Bachmann C,. Age-related reference values for urinary organic acids in a healthy Turkish pediatric population[J]. Clinical Chemistry, 1994, 40 (6):862-6.