Human Inhibitor of nuclear factor kappa-B kinase subunit epsilon ELISA Kit | IKBKE elisa kit

Human Inhibitor of nuclear factor kappa-B kinase subunit epsilon ELISA Kit

Cat. Num. AAA2880114

• Gene Names: IKBKE; IKKE; IKKI; IKK-E; IKK-i
• Reactivity: Human
• Synonyms: Inhibitor of nuclear factor kappa-B kinase subunit epsilon; Human Inhibitor of nuclear factor kappa-B kinase subunit epsilon ELISA Kit; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; Inducible I kappa-B kinase; IKK-i; IKBKE; IKKE; IKKI; KIAA0151; 2.7.11.10; IKBKE elisa kit

• Reactivity: Human
• Sequence Length: 631

• Assay Type: Sandwich
• Detection Range: 78-5000 pg/mL
• Sensitivity: 49 pg/ml
• Intra-Assay CV: <=8.4%
• Inter-Assay CV: <=11.1%
• Recovery: 108%
• Preparation and Storage: For long term storage, please store the entire kit at -20 degree C.

Typical Testing Data/Standard Curve (for reference only)

NCBI and Uniprot Product Information

• NCBI GI #: 300863151
• NCBI GeneID: 9641
• NCBI Accession #: NP_001180250.1
• NCBI GenBank Nucleotide #: NM_001193321.1
• UniProt Accession #: Q14164; Q3B754; Q3KR43; Q5JTS6; D3DT78
• Molecular Weight: 70,816 Da
• NCBI Official Full Name: inhibitor of nuclear factor kappa-B kinase subunit epsilon isoform 3
• NCBI Official Synonym Full Names: inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
• NCBI Official Symbol: IKBKE
• NCBI Official Synonym Symbols: IKKE; IKKI; IKK-E; IKK-i
• NCBI Protein Information: inhibitor of nuclear factor kappa-B kinase subunit epsilon
• UniProt Protein Name: Inhibitor of nuclear factor kappa-B kinase subunit epsilon
• Protein Family: Inhibitor of nuclear factor kappa-B kinase
• UniProt Gene Name: IKBKE
• UniProt Synonym Gene Names: IKKE; IKKI; KIAA0151; I-kappa-B kinase epsilon; IKK-E; IKK-epsilon; IkBKE; IKK-i
• UniProt Entry Name: IKKE_HUMAN

NCBI Description

IKBKE is a noncanonical I-kappa-B (see MIM 164008) kinase (IKK) that is essential for regulating antiviral signaling pathways. IKBKE has also been identified as a breast cancer (MIM 114480) oncogene and is amplified and overexpressed in over 30% of breast carcinomas and breast cancer cell lines (Hutti et al., 2009 [PubMed 19481526]).[supplied by OMIM, Oct 2009]

Uniprot Description

IKKE: a oncogenic kinase of the IKK family. Phosphorylates inhibitors of NF-kappa-B thus leading to the dissociation of the inhibitor/NF-kappa-B complex and ultimately the degradation of the inhibitor. Plays a pivotal role in coordinating the activation of IRF3 and NF-kappaB in the innate immune response. Its redistribution to PML nuclear bodies upon DNA damage is TOPORS-dependent. Is a breast cancer oncogene that exerts its oncogenic properties through cRel.

Protein type: Protein kinase, Other; Kinase, protein; EC 2.7.11.10; Inhibitor; Protein kinase, Ser/Thr (non-receptor); Other group; IKK family

Chromosomal Location of Human Ortholog: 1q32.1

Cellular Component: cytoplasm; cytosol; endosome membrane; mitochondrial membrane; nucleus; PML body

Molecular Function: ATP binding; IkappaB kinase activity; NF-kappaB-inducing kinase activity; protein binding; ubiquitin protein ligase binding

Biological Process: DNA damage response, signal transduction resulting in induction of apoptosis; I-kappaB phosphorylation; immune response; innate immune response; MyD88-independent toll-like receptor signaling pathway; negative regulation of interferon type I production; positive regulation of I-kappaB kinase/NF-kappaB cascade; protein amino acid phosphorylation; protein homooligomerization; toll-like receptor 3 signaling pathway; toll-like receptor 4 signaling pathway; toll-like receptor signaling pathway