Betaine-Homocysteine Methyltransferase 2 Recombinant Protein | BHMT2 recombinant protein

Recombinant Human Betaine-Homocysteine Methyltransferase 2

Cat. Num. AAA145836

• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Synonyms: Betaine-Homocysteine Methyltransferase 2; Recombinant Human Betaine-Homocysteine Methyltransferase 2; BHMT2; Betaine--Homocysteine S-Methyltransferase 2; SMM-Hcy Methyltransferase; S-Methylmethionine--Homocysteine S-Methyltransferase BHMT2; EC 2.1.1.10; EC 2.1.1.5.; BHMT2 recombinant protein

• Host: E Coli
• Purity/Purification: Greater than 90.0% as determined by SDS-PAGE.
• Form/Format: BHMT2 protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 0.4M Urea and 10% glycerol.
• Sequence: MGSSHHHHHH SSGLVPRGSH MGSMAPAGRP GAKKGILERL ESGEVVIGDG SFLITLEKRG YVKAGLWTPE AVIEHPDAVR QLHMEFLRAG SNVMQTFTFS ASEDNMESKW EDVNAAACDL AREVAGKGDA LVAGGICQTS IYKYQKDEAR IKKLFRQQLE VFAWKNVDFL IAEYFEHVEE AVWAVEVLKE SDRPVAVTMC IGPEGDMHDI TPGECAVRLV KAGASIVGVN CRFGPDTSLK TMELMKEGLE WAGLKAHLMV QPLGFHAPDC GKEGFVDLPE YPFGLESRVA TRWDIQKYAR EAYNLGVRYI GGCCGFEPYH IRAIAEELAP ERGFLPPASE KHGSWGSGLD MHTKPWIRAR ARREYWENLL PASGRPFCPS LSKPDF
• Sequence Length: 363

• Physical Appearance: Sterile Filtered colorless solution.
• Preparation and Storage: Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time.; For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).; Avoid multiple freeze-thaw cycles.

Related Product Information for BHMT2 recombinant protein

Description: BHMT2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 386 amino acids (1-363 a.a.) and having a molecular mass of 42.7kDa. BHMT2 is fused to a 23 amino acid His-tag at N-terminus.

Product Categories/Family for BHMT2 recombinant protein

Enzymes

NCBI and Uniprot Product Information

• NCBI GI #: 11907831
• NCBI GeneID: 23743
• Molecular Weight: 33,167 Da
• NCBI Official Full Name: betaine-homocysteine methyltransferase 2
• NCBI Official Synonym Full Names: betaine--homocysteine S-methyltransferase 2
• NCBI Official Symbol: BHMT2
• NCBI Protein Information: S-methylmethionine--homocysteine S-methyltransferase BHMT2; SMM-hcy methyltransferase; betaine-homocysteine methyltransferase 2
• UniProt Protein Name: S-methylmethionine--homocysteine S-methyltransferase BHMT2
• Protein Family: S-methylmethionine--homocysteine S-methyltransferase
• UniProt Gene Name: BHMT2
• UniProt Synonym Gene Names: SMM-hcy methyltransferase
• UniProt Entry Name: BHMT2_HUMAN

NCBI Description

Homocysteine is a sulfur-containing amino acid that plays a crucial role in methylation reactions. Transfer of the methyl group from betaine to homocysteine creates methionine, which donates the methyl group to methylate DNA, proteins, lipids, and other intracellular metabolites. The protein encoded by this gene is one of two methyl transferases that can catalyze the transfer of the methyl group from betaine to homocysteine. Anomalies in homocysteine metabolism have been implicated in disorders ranging from vascular disease to neural tube birth defects such as spina bifida. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2010]

Uniprot Description

BHMT2: Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor. 2 isoforms of the human protein are produced by alternative splicing.

Protein type: Methyltransferase; EC 2.1.1.10

Chromosomal Location of Human Ortholog: 5q13

Cellular Component: cytosol

Molecular Function: betaine-homocysteine S-methyltransferase activity; homocysteine S-methyltransferase activity; zinc ion binding

Biological Process: methylation; S-methylmethionine cycle; S-adenosylmethionine metabolic process; S-methylmethionine metabolic process; betaine metabolic process