B-cell lymphoma/leukemia 10 Recombinant Protein | BCL10 recombinant protein

Recombinant Human B-cell lymphoma/leukemia 10

Cat. Num. AAA9420032

• Gene Names: BCL10; CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
• Reactivity: Human
• Purity: Greater than 90% as determined by SDS-PAGE.
• Synonyms: B-cell lymphoma/leukemia 10; Recombinant Human B-cell lymphoma/leukemia 10; B-cell CLL/lymphoma 10; hCLAPCED-3/ICH-1 prodomain homologous E10-like regulator; CIPER; Cellular homolog of vCARMEN; cCARMENCellular-E10; c-E10Mammalian CARD-containing adapter molecule E10; mE10; BCL10 recombinant protein

• Host: E Coli
• Reactivity: Human
• Purity/Purification: Greater than 90% as determined by SDS-PAGE.
• Form/Format: 20mM Tris-HCl based buffer, pH8.0
• Sequence Positions: Full Length, 1-233aa

• Tag Info: His-SUMO-tag
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C. Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for BCL10 recombinant protein

Involved in adaptive immune response. Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Is a substrate for MALT1.

NCBI and Uniprot Product Information

• NCBI GI #: 4502379
• NCBI GeneID: 8915
• NCBI Accession #: NP_003912.1
• NCBI GenBank Nucleotide #: NM_003921.4
• UniProt Accession #: O95999; Q5VUF1
• Molecular Weight: 42.2kD
• NCBI Official Full Name: B-cell lymphoma/leukemia 10 isoform 1
• NCBI Official Synonym Full Names: B-cell CLL/lymphoma 10
• NCBI Official Symbol: BCL10
• NCBI Official Synonym Symbols: CLAP; mE10; CIPER; IMD37; c-E10; CARMEN
• NCBI Protein Information: B-cell lymphoma/leukemia 10
• UniProt Protein Name: B-cell lymphoma/leukemia 10
• Protein Family: B-cell lymphoma/leukemia
• UniProt Gene Name: BCL10
• UniProt Synonym Gene Names: CIPER; CLAP; Bcl-10; hCLAP; CIPER; cCARMEN; c-E10; mE10

NCBI Description

This gene was identified by its translocation in a case of mucosa-associated lymphoid tissue (MALT) lymphoma. The protein encoded by this gene contains a caspase recruitment domain (CARD), and has been shown to induce apoptosis and to activate NF-kappaB. This protein is reported to interact with other CARD domain containing proteins including CARD9, 10, 11 and 14, which are thought to function as upstream regulators in NF-kappaB signaling. This protein is found to form a complex with MALT1, a protein encoded by another gene known to be translocated in MALT lymphoma. MALT1 and this protein are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016]

Uniprot Description

Bcl-10: a ubiquitous pro-apoptotic protein that promotes pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK. May be an adapter protein between upstream TNFR1-TRADD-RIP complex and the downstream NIK-IKK-IKAP complex. Self-associates via CARD-CARD interactions; forms a tight complex with MALT1. Interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2. Defects in BCL10 are involved in various types of cancer.

Protein type: Apoptosis; Transcription, coactivator/corepressor; Tumor suppressor

Chromosomal Location of Human Ortholog: 1p22.3

Cellular Component: cytoplasm; cytoplasmic microtubule; cytosol; lipopolysaccharide receptor complex; lysosome; nucleus; perinuclear region of cytoplasm; plasma membrane; protein complex; T cell receptor complex

Molecular Function: enzyme binding; identical protein binding; kinase activator activity; kinase binding; NF-kappaB binding; protease binding; protein binding; protein C-terminus binding; protein kinase B binding; protein kinase binding; protein self-association; transcription coactivator activity; transcription factor binding; ubiquitin binding; ubiquitin protein ligase binding

Biological Process: activation of NF-kappaB transcription factor; adaptive immune response; cell death; innate immune response; negative regulation of mature B cell apoptosis; neural tube closure; positive regulation of I-kappaB kinase/NF-kappaB cascade; positive regulation of interleukin-8 biosynthetic process; positive regulation of phosphorylation; positive regulation of protein ubiquitination; positive regulation of transcription, DNA-dependent; protein homooligomerization; protein oligomerization; protein ubiquitination; response to food; response to molecule of bacterial origin; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; toll-like receptor signaling pathway

Disease: Follicular Lymphoma, Susceptibility To, 1; Gastric Lymphoma, Primary; Immunodeficiency 37; Lymphoma, Non-hodgkin, Familial; Mesothelioma, Malignant; Testicular Germ Cell Tumor