BCL2-Associated Athanogene 2 Recombinant Protein | BAG2 recombinant protein
Recombinant Human BCL2-Associated Athanogene 2
Gene Names
BAG2; BAG-2; dJ417I1.2
Purity
Greater than 95.0% as determined by SDS-PAGE.
Synonyms
BCL2-Associated Athanogene 2; Recombinant Human BCL2-Associated Athanogene 2; BAG2 Human; BCL2-Associated Athanogene 2 Human Recombinant; BAG family molecular chaperone regulator 2; BAG-2; Bcl-2-associated athanogene 2; BAG2; KIAA0576; MGC149462; dJ417I1.2; BAG2 recombinant protein
Host
E Coli
Purity/Purification
Greater than 95.0% as determined by SDS-PAGE.
Form/Format
The BAG2 solution (1 mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 1mM DTT, 20% glycerol and 0.1M NaCl.
Sterile Filtered colorless solution.
Sterile Filtered colorless solution.
Sequence
MGSSHHHHHH SSGLVPRGSH MAQAKINAKA NEGRFCRSSS MADRSSRLLE SLDQLELRVE ALREAATAVE QEKEILLEMI HSIQNSQDMR QISDGEREEL NLTANRLMGR TLTVEVSVET IRNPQQQESL KHATRIIDEV VNKFLDDLGN AKSHLMSLYS ACSSEVPHGP VDQKFQSIVI GCALEDQKKI KRRLETLLRN IENSDKAIKL LEHSKGAGSK TLQQNAESRF N
Sequence Length
211
Related Product Information for BAG2 recombinant protein
Introduction: BCL2-associated athanogene 2 (BAG2) belongs to the Bag family of proteins. BAG2 is a chief component of the HSC 70/CHIP chaperone-dependent ubiquitin ligase complex and acts to upset CHIP-mediated ubiquitylation. BAG proteins compete with Hip for attaching to the Hsc70/Hsp70 ATPase domain and promote substrate discharge. All the BAG proteins have a roughly 45 amino acid BAG domain by the C-terminus but vary clearly in their N-terminal regions. The BAG domains of BAG1, BAG2, and BAG3 act together expressly with the Hsc70 ATPase domain in vitro and in mammalian cells. All three proteins attach with high affinity to the ATPase domain of Hsc70 and obstruct its chaperone activity in a Hip-repressible manner.
Product Categories/Family for BAG2 recombinant protein
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
20,189 Da
NCBI Official Full Name
BAG family molecular chaperone regulator 2
NCBI Official Synonym Full Names
BCL2-associated athanogene 2
NCBI Official Symbol
BAG2
NCBI Official Synonym Symbols
BAG-2; dJ417I1.2
NCBI Protein Information
BAG family molecular chaperone regulator 2; BAG-family molecular chaperone regulator-2; bcl-2-associated athanogene 2; dJ417I1.2 (BAG-family molecular chaperone regulator 2)
UniProt Protein Name
BAG family molecular chaperone regulator 2
Protein Family
UniProt Gene Name
BAG2
UniProt Synonym Gene Names
BAG-2
UniProt Entry Name
BAG2_HUMAN
NCBI Description
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Uniprot Description
BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 6p12.1-p11.2
Molecular Function: identical protein binding; protein binding; chaperone binding
Biological Process: protein folding; protein metabolic process
