Western Blot (WB)
(Anti-BAG2 antibody, MBS176358, Western blottingLane 1: Rat Testis Tissue LysateLane 2: HELA Cell LysateLane 3: A549 Cell LysateLane 4: A431 Cell Lysate )
Rabbit BAG2 Polyclonal Antibody | anti-BAG2 antibody
Anti-BAG2 antibody
Gene Names
BAG2; BAG-2; dJ417I1.2
Reactivity
Human, Mouse, Rat
Applications
Western Blot
Purity
Immunogen affinity purified.
Synonyms
BAG2; Polyclonal Antibody; Anti-BAG2 antibody; BAG family molecular chaperone regulator 2; BCL2-associated athanogene 2; BAG 2 antibody; BAG family molecular chaperone regulator 2 antibody; BAG-2 antibody; BAG-family molecular chaperone regulator-2 antibody; Bag2 antibody; BAG2_HUMAN antibody; BCL 2 associated athanogene 2 antibody; Bcl-2-associated athanogene 2 antibody; BCL2 associated athanogene 2 antibody; BCL2-associated athanogene 2 antibody; dJ417I1.2(BAG family molecular chaperone regulator 2) antibody; dJ417I1.2 antibody; KIAA0576 antibody; MGC149462 antibody; OTTHUMP00000016668 antibody; anti-BAG2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Purity/Purification
Immunogen affinity purified.
Form/Format
Lyophilized
Sequence Length
211
Applicable Applications for anti-BAG2 antibody
Western Blot (WB)
Immunogen
A synthetic peptide corresponding to a sequence at the N-terminus of human BAG2 (1-14aa MAQAKINAKANEGR), different from the related mouse and rat sequences by two amino acids.
Contents
Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3.
Reconstitution
Add 0.2ml of distilled water will yield a concentration of 500ug/ml.
Preparation and Storage
At -20 degree C for one year. After reconstitution, at 4 degree C for one month. It can also be aliquotted and stored frozen at -20 degree C for a longer time. Avoid repeated freezing and thawing.
Western Blot (WB)
(Anti-BAG2 antibody, MBS176358, Western blottingLane 1: Rat Testis Tissue LysateLane 2: HELA Cell LysateLane 3: A549 Cell LysateLane 4: A431 Cell Lysate )
Western Blot (WB)
(Anti-BAG2 antibody, MBS176358, Western blottingLane 1: Rat Testis Tissue LysateLane 2: HELA Cell LysateLane 3: A549 Cell LysateLane 4: A431 Cell Lysate )
Related Product Information for anti-BAG2 antibody
Description: Rabbit IgG polyclonal antibody for BAG family molecular chaperone regulator 2(BAG2) detection. Tested with WB in Human, Mouse, Rat.
Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.
Background: BAG family molecular chaperone regulator 2 is a protein that in humans is encoded by the BAG2 gene. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. The functional antagonisms displayed between BAG family proteins and Hip suggest that a proper balance of these 2 types of protein is required for achieving optimal cycles of substrate binding and release required for inducting conformational changes in proteins, with Hip promoting peptide substrate binding by Hsc70/Hsp70 and BAG family proteins promoting dissociation.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
Molecular Weight
20,189 Da
NCBI Official Full Name
BAG family molecular chaperone regulator 2
NCBI Official Synonym Full Names
BCL2-associated athanogene 2
NCBI Official Symbol
BAG2
NCBI Official Synonym Symbols
BAG-2; dJ417I1.2
NCBI Protein Information
BAG family molecular chaperone regulator 2; bcl-2-associated athanogene 2; BAG-family molecular chaperone regulator-2; dJ417I1.2 (BAG-family molecular chaperone regulator 2)
UniProt Protein Name
BAG family molecular chaperone regulator 2
Protein Family
UniProt Gene Name
BAG2
UniProt Synonym Gene Names
BAG-2
UniProt Entry Name
BAG2_HUMAN
NCBI Description
BAG proteins compete with Hip for binding to the Hsc70/Hsp70 ATPase domain and promote substrate release. All the BAG proteins have an approximately 45-amino acid BAG domain near the C terminus but differ markedly in their N-terminal regions. The predicted BAG2 protein contains 211 amino acids. The BAG domains of BAG1, BAG2, and BAG3 interact specifically with the Hsc70 ATPase domain in vitro and in mammalian cells. All 3 proteins bind with high affinity to the ATPase domain of Hsc70 and inhibit its chaperone activity in a Hip-repressible manner. [provided by RefSeq, Jul 2008]
Uniprot Description
BAG2: Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release.
Protein type: Apoptosis
Chromosomal Location of Human Ortholog: 6p12.1-p11.2
Molecular Function: identical protein binding; protein binding; chaperone binding
Biological Process: protein folding; protein metabolic process
Research Articles on BAG2
Similar Products
Product Notes
The BAG2 bag2 (Catalog #AAA176358) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The Anti-BAG2 antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's BAG2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB). Researchers should empirically determine the suitability of the BAG2 bag2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "BAG2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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