SPHK1a Active Protein | Sphk1 active protein
SPHK1a, Recombinant, Mouse (Sphingosine kinase 1a)
50% by SDS-PAGE
50% by SDS-PAGE
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a kinase that phosphorylates sphingosine into sphingosine-1-phosphate, which is involved in cell differentiation, motility, and apoptosis. The encoded protein plays a role in maintaining cellular levels of sphingosine-1-phosphate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
Uniprot Description
SPHK1: Catalyzes the phosphorylation of sphingosine to form sphingosine 1-phosphate (SPP), a lipid mediator with both intra- and extracellular functions. Also acts on D-erythro-sphingosine and to a lesser extent sphinganine, but not other lipids, such as D,L-threo-dihydrosphingosine, N,N-dimethylsphingosine, diacylglycerol, ceramide, or phosphatidylinositol. Interacts with ACY1. Binds to calmodulin. Interacts with SPHKAP. Widely expressed with highest levels in adult liver, kidney, heart and skeletal muscle. 2 isoforms of the human protein are produced by alternative splicing.
Protein type: Kinase, lipid; Lipid Metabolism - sphingolipid; EC 2.7.1.91
Cellular Component: synaptic vesicle; neuron projection; membrane; axon; cytoplasm; plasma membrane; nucleus; cytosol
Molecular Function: transferase activity; calmodulin binding; D-erythro-sphingosine kinase activity; DNA binding; protein phosphatase 2A binding; sphinganine kinase activity; nucleotide binding; magnesium ion binding; kinase activity; diacylglycerol kinase activity; ATP binding; NAD+ kinase activity
Biological Process: blood vessel development; metabolic process; cyclooxygenase pathway; calcium-mediated signaling; positive regulation of NF-kappaB import into nucleus; sphingosine metabolic process; positive regulation of mitotic cell cycle; lipid phosphorylation; positive regulation of neurotransmitter secretion; positive regulation of cell growth; activation of NF-kappaB transcription factor; positive regulation of angiogenesis; positive regulation of fibroblast proliferation; positive regulation of protein ubiquitination; regulation of interleukin-1 beta production; protein kinase C activation; positive regulation of cell proliferation; positive regulation of smooth muscle contraction; positive regulation of protein amino acid phosphorylation; brain development; inflammatory response; phosphorylation; positive regulation of cell migration; negative regulation of apoptosis
Research Articles on Sphk1
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Product Notes
The Sphk1 sphk1 (Catalog #AAA635669) is an Active Protein produced from Baculovirus infected Sf9 cells and is intended for research purposes only. The product is available for immediate purchase. Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. Researchers should empirically determine the suitability of the Sphk1 sphk1 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "SPHK1a, Active Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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