CD200R1 active protein

Recombinant CD200R1

Cat. Num. AAA201075

• Gene Names: CD200R1; OX2R; MOX2R; CD200R; HCRTR2
• Applications: SDS-Page
• Purity: >90% by SDS-PAGE
• Synonyms: CD200R1; Recombinant CD200R1; Cell surface glycoprotein CD200 receptor 1 isoform d; CD200R; HCRTR2; MOX2R; OX2R; CD200R1 active protein

• Host: Baculovirus
• Purity/Purification: >90% by SDS-PAGE
• Form/Format: Liquid; In Phosphate Buffered Saline (pH 7.4) Containing 10% Glycerol.
• Concentration: 0.25mg/ml (determined by Absorbance at 280nm) (varies by lot)
• Sequence Positions: 24-243aa
• Sequence: ADLSSSLCMD EKQITQNYSK VLAEVNTSWP VKMATNAVLC CPPIALRNLI IITWEIILRG QPSCTKAYKK ETNETKETNC TDERITWVSR PDQNSDLQIR TVAITHDGYY RCIMVTPDGN FHRGYHLQVL VTPEVTLFQN RNRTAVCKAV AGKPAAHISW IPEGDCATKQ EYWSNGTVTV KSTCHWEVHN VSTVTCHVSH LTGNKSLYIE LLPVPGAKKS AKLLEPKSCD KTHTCPPCPA PELLGGPSVF LFPPKPKDTL MISRTPEVTC VVVDVSHEDP EVKFNWYVDG VEVHNAKTKP REEQYNSTYR VVSVLTVLHQ DWLNGKEYKC KVSNKALPAP IEKTISKAKG QPREPQVYTL PPSRDELTKN QVSLTCLVKG FYPSDIAVEW ESNGQPENNY KTTPPVLDSD GSFFLYSKLT VDKSRWQQGN VFSCSVMHEA LHNHYTQKSL SLSPGKHHHH HH
• Sequence Length: 348

• Applicable Applications for CD200R1 active protein: SDS-PAGE
• Species: Human
• Endotoxin: <1.0 EU per 1ug of protein (determined by LAL method)
• Tag: hIgG-His-Tag
• Predicted N-Terminal: Ala
• Preparation and Storage: Can be stored at 2 degree C to 8 degree C for 1 week. For long term storage, aliquot and store at -20 degree C to -80 degree C. Avoid repeated freezing and thawing cycles.

SDS-Page

(3ug by SDS-PAGE under reducing condition and visualized by coomassie blue stain )

Related Product Information for CD200R1 active protein

CD200R1, also known as cell surface glycoprotein CD200 receptor 1 isoform d, is a transmembrane protein in the immunoglobulin superfamily. This glycoprotein contains on C2 type Ig-like domain and V type Ig-like domain within its extracellular domain and a PTB-signaling motif in cytoplasmic domain. Also, it is expressed on myeloid cells and CD4+ T cells. For function, this receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid down regulatory signal. Activation of CD200R1 regulates the expression of inflammatory molecules such as tumor necrosis factor (TNF-alpha), interferon and inducible nitric oxide synthase (iNOS). Recombinant human CD200R1, fused to hIgG-His-tag at C-terminus, was expressed in insect cell and purified by using conventional chromatography techniques.

Product Categories/Family for CD200R1 active protein

Immunology

References

Wright GJ., et al, (2003) J. Immunol. 171:3034-3046. Liu JQ., et al, (2016) J. Immunol. 197:1489-1497.

NCBI and Uniprot Product Information

• NCBI GI #: 20270365
• NCBI GeneID: 131450
• NCBI Accession #: NP_620161.1
• NCBI GenBank Nucleotide #: NP_620161.1
• UniProt Accession #: Q8TD46
• Molecular Weight: 51.9kDa (462aa); 50-70kDa (SDS-PAGE under reducing conditions)
• NCBI Official Full Name: cell surface glycoprotein CD200 receptor 1 isoform a
• NCBI Official Synonym Full Names: CD200 receptor 1
• NCBI Official Symbol: CD200R1
• NCBI Official Synonym Symbols: OX2R; MOX2R; CD200R; HCRTR2
• NCBI Protein Information: cell surface glycoprotein CD200 receptor 1
• UniProt Protein Name: Cell surface glycoprotein CD200 receptor 1
• Protein Family: Cell surface glycoprotein CD200 receptor
• UniProt Gene Name: CD200R1
• UniProt Synonym Gene Names: CD200R; CRTR2; MOX2R; OX2R
• UniProt Entry Name: MO2R1_HUMAN

NCBI Description

This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

Uniprot Description

CD200R: Receptor for the CD200/OX2 cell surface glycoprotein. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200. Belongs to the CD200R family. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Membrane protein, integral; Receptor, misc.

Chromosomal Location of Human Ortholog: 3q13.2

Cellular Component: integral to membrane; extracellular region; plasma membrane; receptor complex

Molecular Function: protein binding

Biological Process: regulation of immune response; viral reproduction