Beta-secretase 2 (Bace2) Recombinant Protein | Bace2 recombinant protein
Recombinant Rat Beta-secretase 2 (Bace2), partial
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Beta-secretase 2 (Bace2); Recombinant Rat Beta-secretase 2 (Bace2); partial; Bace2 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
21-469
Sequence
VPVLAPAPFT LPLQVAGAAN HRASTVPGLG TPELPRADGL ALALEPARAT ANFLAMVDNL QGDSGRGYYL EMLIGTPPQK VRILVDTGSS NFAVAGAPHS YIDTYFDSES SSTYHSKGFE VTVKYTQGSW TGFVGEDLVT IPKGFNSSFL VNIATIFESE NFFLPGIKWN GILGLAYAAL AKPSSSLETF FDSLVAQAKI PDIFSMQMCG AGLPVAGSGT NGGSLVLGGI EPSLYKGDIW YTPIKEEWYY QIEILKLEIG GQSLNLDCRE YNADKAIVDS GTTLLRLPQK VFDAVVEAVA RTSLIPEFSD GFWTGAQLAC WTNSETPWAY FPKISIYLRD ENASRSFRIT ILPQLYIQPM MGAGFNYECY RFGISSSTNA LVIGATVMEG FYVVFDRAQR RVGFAVSPCA EIAGTTVSEI SGPFSTEDIA SNCVPAQALN EPILWIVSY
Sequence Length
449
Species
Rat
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for Bace2 recombinant protein
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer s disease and a frequent complication of Down syndrome. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein by 2 proteases, one of which is This protein. This gene localizes to the Down critical region of chromosome 21. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease. Three transcript variants encoding different isoforms have been described for this gene.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
55,858 Da
NCBI Official Full Name
beta-secretase 2
NCBI Official Synonym Full Names
beta-site APP-cleaving enzyme 2
NCBI Official Symbol
Bace2
NCBI Protein Information
beta-secretase 2
UniProt Protein Name
Beta-secretase 2
Protein Family
UniProt Gene Name
Bace2
UniProt Synonym Gene Names
Beta-site APP cleaving enzyme 2
Uniprot Description
Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672 ().
Research Articles on Bace2
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Product Notes
The Bace2 bace2 (Catalog #AAA1317482) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 21-469. The amino acid sequence is listed below: VPVLAPAPFT LPLQVAGAAN HRASTVPGLG TPELPRADGL ALALEPARAT ANFLAMVDNL QGDSGRGYYL EMLIGTPPQK VRILVDTGSS NFAVAGAPHS YIDTYFDSES SSTYHSKGFE VTVKYTQGSW TGFVGEDLVT IPKGFNSSFL VNIATIFESE NFFLPGIKWN GILGLAYAAL AKPSSSLETF FDSLVAQAKI PDIFSMQMCG AGLPVAGSGT NGGSLVLGGI EPSLYKGDIW YTPIKEEWYY QIEILKLEIG GQSLNLDCRE YNADKAIVDS GTTLLRLPQK VFDAVVEAVA RTSLIPEFSD GFWTGAQLAC WTNSETPWAY FPKISIYLRD ENASRSFRIT ILPQLYIQPM MGAGFNYECY RFGISSSTNA LVIGATVMEG FYVVFDRAQR RVGFAVSPCA EIAGTTVSEI SGPFSTEDIA SNCVPAQALN EPILWIVSY. It is sometimes possible for the material contained within the vial of "Beta-secretase 2 (Bace2), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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