Beta-secretase 1 Recombinant Protein | Bace1 recombinant protein

Beta-secretase 1

Cat. Num. AAA7042349

• Gene Names: Bace1; ASP2; Bace; C76936
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Beta-secretase 1; Bace1 recombinant protein

• Host: Cell Free Expression
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Liquid containing glycerol
• Sequence Positions: 46-501aa; full length protein
• Sequence: ETDEESEEPGRRGSFVEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSSTYRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGILGLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGIDHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKKVFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRITILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSACHVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQWRCLRCLRHQHDDFADDISLLK
• Sequence Length: Full Length Protein

• Species: Mus musculus (Mouse)
• Preparation and Storage: Store at -20 degree C, for extended storage, conserve at -20 degree C or -80 degree C.; Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.

Related Product Information for Bace1 recombinant protein

This is a recombinant transmembrane protein expressed in a cell-free expression system.

Product Categories/Family for Bace1 recombinant protein

Transmembrane Protein

NCBI and Uniprot Product Information

• NCBI GI #: 225543122
• NCBI GeneID: 23821
• NCBI Accession #: NP_001139419.1
• NCBI GenBank Nucleotide #: NM_001145947.2
• UniProt Accession #: P56818; Q544D0
• Molecular Weight: 55,748 Da
• NCBI Official Full Name: beta-secretase 1 isoform 2
• NCBI Official Synonym Full Names: beta-site APP cleaving enzyme 1
• NCBI Official Symbol: Bace1
• NCBI Official Synonym Symbols: ASP2; Bace; C76936
• NCBI Protein Information: beta-secretase 1
• UniProt Protein Name: Beta-secretase 1
• Protein Family: Beta-secretase
• UniProt Gene Name: Bace1
• UniProt Synonym Gene Names: Bace; ASP2; Asp 2; Beta-site APP cleaving enzyme 1
• UniProt Entry Name: BACE1_MOUSE

NCBI Description

This gene encodes a member of the peptidase A1 family of aspartic proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature protease. This transmembrane protease catalyzes the first step in the formation of amyloid beta peptide from amyloid precursor protein. Amyloid beta peptides are the main constituent of amyloid beta plaques, which accumulate in the brains of human Alzheimer's disease patients. Homozygous knockout mice for this gene exhibit a wide range of nervous system defects, growth retardation, metabolic abnormalities, and increased neonatal lethality. [provided by RefSeq, Nov 2015]

Uniprot Description

BACE: an integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Cleaves APP at the amino terminus of the A-beta peptide sequence, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated carboxy-terminal fragment which is later release by gamma-secretase. Four splice-variant isoforms have been described.

Protein type: Membrane protein, integral; EC 3.4.23.46; Protease

Cellular Component: axon; cytoplasmic vesicle; endosome; Golgi apparatus; integral to plasma membrane; late endosome; membrane; multivesicular body; plasma membrane; trans-Golgi network

Molecular Function: aspartic-type endopeptidase activity; beta-amyloid binding; endopeptidase activity; enzyme binding; peptidase activity; protein binding

Biological Process: beta-amyloid metabolic process; membrane protein ectodomain proteolysis; protein catabolic process; proteolysis