Ancient ubiquitous protein 1 (AUP1) Recombinant Protein | AUP1 recombinant protein

Recombinant Human Ancient ubiquitous protein 1 (AUP1), partial

Cat. Num. AAA1379433

• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Ancient ubiquitous protein 1 (AUP1); Recombinant Human Ancient ubiquitous protein 1 (AUP1); partial; AUP1 recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Positions: 42-476
• Sequence: RLFLGIHVF LVSCALPDSV LRRFVVRTMC AVLGLVARQE DSGLRDHSVR VLISNHVTPF DHNIVNLLTT CSTVSESEAE SATGRFPGAQ LKAPLSPLAF RMEDTEALPL TPILYPTCQF FFFIFLNIFL LAFSSPGSQP LLNSPPSFVC WSRGFMEMNG RGELVESLKR FCASTRLPPT PLLLFPEEEA TNGREGLLRF SSWPFSIQDV VQPLTLQVQR PLVSVTVSDA SWVSELLWSL FVPFTVYQVR WLRPVHRQLG EANEEFALRV QQLVAKELGQ TGTRLTPADK AEHMKRQRHP RLRPQSAQSS FPPSPGPSPD VQLATLAQRV KEVLPHVPLG VIQRDLAKTG CVDLTITNLL EGAVAFMPED ITKGTQSLPT ASASKFPSSG PVTPQPTALT FAKSSWARQE SLQERKQALY EYARRRFTER RAQEAD
• Sequence Length: 435

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

Related Product Information for AUP1 recombinant protein

This gene encodes a protein that contains a domain with homology to the ancient conserved region of the archain 1 gene and a domain that may be involved in binding ubiquitin-conjugating enzymes. This protein has been shown to bind to the conserved membrane-proximal sequence of the cytoplasmic tail of integrin alpha(IIb) subunits. These subunits play a crucial role in the integrin alpha(IIb)beta(3) inside-out signalling in platelets and megakaryocytes that leads to platelet aggregation and thrombus formation. This gene overlaps the gene for mitochondrial serine protease 25.

NCBI and Uniprot Product Information

• NCBI GI #: 31712030
• NCBI GeneID: 550
• NCBI Accession #: NP_853553.1
• NCBI GenBank Nucleotide #: NM_181575.4
• UniProt Accession #: Q9Y679; Q9H866; Q9UNQ6; Q9Y685; C0H5W8
• Molecular Weight: 41,385 Da
• NCBI Official Full Name: ancient ubiquitous protein 1
• NCBI Official Synonym Full Names: AUP1, lipid droplet regulating VLDL assembly factor
• NCBI Official Symbol: AUP1
• NCBI Protein Information: ancient ubiquitous protein 1
• UniProt Protein Name: Ancient ubiquitous protein 1
• Protein Family: Ancient ubiquitous protein
• UniProt Gene Name: AUP1

NCBI Description

The protein encoded this gene is involved in several pathways including quality control of misfolded proteins in the endoplasmic reticulum and lipid droplet accumulation. Lipid droplets are organelles in the cytoplasm that store neutral lipids such as cholesterol esters and trigylycerides to prevent the overabundance of free cholesterol and fatty acids in cells, but also to act as storage for other metabolic processes, such as membrane biogenesis. Reduced expression of this gene results in reduced lipid droplet clustering, a function that is dependent on ubiquitination of the protein. This protein contains multiple domains including a hydrophobic N-terminal domain, an acetyltranferase domain, a ubiquitin-binding CUE domain, and a UBE2B2-binding domain (G2BR). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]

Uniprot Description

May play a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome.