Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) Recombinant Protein | ATP2A1 recombinant protein
Recombinant Human Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1) , partial
NCBI and Uniprot Product Information
NCBI Description
This gene encodes one of the SERCA Ca(2+)-ATPases, which are intracellular pumps located in the sarcoplasmic or endoplasmic reticula of muscle cells. This enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen, and is involved in muscular excitation and contraction. Mutations in this gene cause some autosomal recessive forms of Brody disease, characterized by increasing impairment of muscular relaxation during exercise. Alternative splicing results in three transcript variants encoding different isoforms. [provided by RefSeq, Oct 2013]
Uniprot Description
Key regulator of striated muscle performance by acting as the major Ca2+ ATPase responsible for the reuptake of cytosolic Ca2+ into the sarcoplasmic reticulum. Catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Contributes to calcium sequestration involved in muscular excitation/contraction.
Research Articles on ATP2A1
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Product Notes
The ATP2A1 atp2a1 (Catalog #AAA1044680) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 314-757aa; Partial. The amino acid sequence is listed below: VITTCLALGT RRMAKKNAIV RSLPSVETLG CTSVICSDKT GTLTTNQMSV CKMFIIDKVD GDICLLNEFS ITGSTYAPEG EVLKNDKPVR PGQYDGLVEL ATICALCNDS SLDFNEAKGV YEKVGEATET ALTTLVEKMN VFNTDVRSLS KVERANACNS VIRQLMKKEF TLEFSRDRKS MSVYCSPAKS SRAAVGNKMF VKGAPEGVID RCNYVRVGTT RVPLTGPVKE KIMAVIKEWG TGRDTLRCLA LATRDTPPKR EEMVLDDSAR FLEYETDLTF VGVVGMLDPP RKEVTGSIQL CRDAGIRVIM ITGDNKGTAI AICRRIGIFG ENEEVADRAY TGREFDDLPL AEQREACRRA CCFARVEPSH KSKIVEYLQS YDEITAMTGD GVNDAPALKK AEIGIAMGSG TAVAKTASEM VLADDNFSTI VAAVEEGRAI YNNM . It is sometimes possible for the material contained within the vial of "Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 (ATP2A1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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