Abnormal spindle-like microcephaly-associated protein (ASPM) Recombinant Protein | ASPM recombinant protein

Recombinant Human Abnormal spindle-like microcephaly-associated protein (ASPM) , partial

• Gene Names: ASPM; ASP; MCPH5; Calmbp1
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: Abnormal spindle-like microcephaly-associated protein (ASPM); Recombinant Human Abnormal spindle-like microcephaly-associated protein (ASPM); partial; ASPM recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 1,892

• Species: Human
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 332205965
• NCBI GeneID: 259266
• NCBI Accession #: NP_001193775.1
• NCBI GenBank Nucleotide #: NM_001206846.1
• UniProt Accession #: Q8IZT6; Q4G1H1; Q5VYL3; Q86UX4; Q8IUL2; Q8IZJ7; Q8IZJ8; Q8IZJ9; Q8N4D1; Q9NVS1; Q9NVT6
• Molecular Weight: 217,794 Da
• NCBI Official Full Name: abnormal spindle-like microcephaly-associated protein isoform 2
• NCBI Official Synonym Full Names: abnormal spindle microtubule assembly
• NCBI Official Symbol: ASPM
• NCBI Official Synonym Symbols: ASP; MCPH5; Calmbp1
• NCBI Protein Information: abnormal spindle-like microcephaly-associated protein
• UniProt Protein Name: Abnormal spindle-like microcephaly-associated protein
• Protein Family: Abnormal spindle-like microcephaly-associated protein
• UniProt Gene Name: ASPM
• UniProt Synonym Gene Names: MCPH5; Asp homolog

NCBI Description

This gene is the human ortholog of the Drosophila melanogaster 'abnormal spindle' gene (asp), which is essential for normal mitotic spindle function in embryonic neuroblasts. Studies in mouse also suggest a role of this gene in mitotic spindle regulation, with a preferential role in regulating neurogenesis. Mutations in this gene are associated with microcephaly primary type 5. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, May 2011]

Uniprot Description

Involved in mitotic spindle regulation and coordination of mitotic processes. The function in regulating microtubule dynamics at spindle poles including spindle orientation, astral microtubule density and poleward microtubule flux seems to depend on the association with the katanin complex formed by KATNA1 and KATNB1. Enhances the microtubule lattice severing activity of KATNA1 by recruiting the katanin complex to microtubules. Can block microtubule minus-end growth and reversely this function can be enhanced by the katanin complex (PubMed:28436967). May have a preferential role in regulating neurogenesis.