AT-rich interactive domain-containing protein 5B (Arid5b) Recombinant Protein | Arid5b recombinant protein

Recombinant Mouse AT-rich interactive domain-containing protein 5B (Arid5b) , partial

• Gene Names: Arid5b; Mrf2; Desrt; AI467247; Mrf2beta; Mrf2alpha; 4930580B11; 5430435G07Rik
• Purity: Greater or equal to 85% purity as determined by SDS-PAGE.
• Synonyms: AT-rich interactive domain-containing protein 5B (Arid5b); Recombinant Mouse AT-rich interactive domain-containing protein 5B (Arid5b); partial; Arid5b recombinant protein

• Host: E Coli or Yeast or Baculovirus or Mammalian Cell
• Purity/Purification: Greater or equal to 85% purity as determined by SDS-PAGE.
• Form/Format: Lyophilized or liquid (Format to be determined during the manufacturing process)
• Sequence Length: 276

• Species: Mouse
• Preparation and Storage: Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.

NCBI and Uniprot Product Information

• NCBI GI #: 74136557
• NCBI GeneID: 71371
• NCBI Accession #: NP_076087.2
• NCBI GenBank Nucleotide #: NM_023598.2
• UniProt Accession #: Q8BM75; Q8C0E0; Q8K4G8; Q8K4L9; Q9CU78; Q9JIX4; E9Q523
• Molecular Weight: 31,400 Da
• NCBI Official Full Name: AT-rich interactive domain-containing protein 5B
• NCBI Official Synonym Full Names: AT rich interactive domain 5B (MRF1-like)
• NCBI Official Symbol: Arid5b
• NCBI Official Synonym Symbols: Mrf2; Desrt; AI467247; Mrf2beta; Mrf2alpha; 4930580B11; 5430435G07Rik
• NCBI Protein Information: AT-rich interactive domain-containing protein 5B
• UniProt Protein Name: AT-rich interactive domain-containing protein 5B
• Protein Family: AT-rich interactive domain-containing protein
• UniProt Gene Name: Arid5b
• UniProt Synonym Gene Names: Desrt; Mrf2; ARID domain-containing protein 5B; Desrt; MRF-2

Uniprot Description

Transcription coactivator that binds to the 5'-AATA[CT]-3' core sequence and plays a key role in adipogenesis and liver development. Acts by forming a complex with phosphorylated PHF2, which mediates demethylation at Lys-337, leading to target the PHF2-ARID5B complex to target promoters, where PHF2 mediates demethylation of dimethylated 'Lys-9' of histone H3 (H3K9me2), followed by transcription activation of target genes. The PHF2-ARID5B complex acts as a coactivator of HNF4A in liver (). Required for adipogenesis: regulates triglyceride metabolism in adipocytes by regulating expression of adipogenic genes. Overexpression leads to induction of smooth muscle marker genes, suggesting that it may also act as a regulator of smooth muscle cell differentiation and proliferation.