APO-D Recombinant Protein | APOD recombinant protein

Recombinant Human APO-D GST Tag

Cat. Num. AAA143615

• Synonyms: APO-D; Recombinant Human APO-D GST Tag; APO D Human; GST; APO-D Human Recombinant; GST Tag; Apolipoprotein D; Apo-D; ApoD; APOD GST; APOD recombinant protein

• Host: E Coli
• Form/Format: APO-D protein at 100 ug/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol.; Sterile Filtered clear solution.
• Sequence Length: 189

• Preparation and Storage: Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.

Related Product Information for APOD recombinant protein

Description: APO-D Human Recombinant full length protein expressed in E Coli, shows a 48 kDa band on SDS-PAGE.The APO-D is purified by proprietary chromatographic techniques.

Introduction: Apolipoprotein-D is mainly associated with high density lipoproteins in human plasma. Apolipoprotein-D is an atypical apolipoprotein and, based on its primary structure, Apolipoprotein-D is a member of the lipocalin family. Lipocalins adopt a beta-barrel tertiary structure and transport small hydrophobic ligands. Apolipoprotein-D binds cholesterol, progesterone, pregnenolone, bilirubin and arachidonic acid. Apolipoprotein-D is expressed in numerous tissues having high levels of expression in spleen, testes and brain. Apolipoprotein-D is present at high concentrations in the cyst fluid of women with gross cystic disease of the breast, a condition associated with increased risk of breast cancer. Apolipoprotein-D accumulates in regenerating peripheral nerves and in the cerebrospinal fluid of patients with neurodegenerative conditions, such as Alzheimer's disease. Apolipoprotein-D participates in maintenance and repair within the central and peripheral nervous systems. Apolipoprotein-D is a multi-ligand, multi-functional transporter and transports a ligand from 1 cell to another within an organ, scavenge a ligand within an organ for transport to the blood or could transport a ligand from the circulation to specific cells within a tissue.

Product Categories/Family for APOD recombinant protein

Cytokines and Growth Factors; Cytokines; Apolipoprotein

NCBI and Uniprot Product Information

• NCBI GI #: 4502163
• NCBI GeneID: 347
• NCBI Accession #: NP_001638.1
• NCBI GenBank Nucleotide #: NM_001647.3
• UniProt Accession #: P05090; Q6IBG6; B2R579; D3DNW6
• Molecular Weight: 21,276 Da
• NCBI Official Full Name: apolipoprotein D
• NCBI Official Synonym Full Names: apolipoprotein D
• NCBI Official Symbol: APOD
• NCBI Protein Information: apolipoprotein D; apo-D
• UniProt Protein Name: Apolipoprotein D
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOD
• UniProt Synonym Gene Names: Apo-D; ApoD
• UniProt Entry Name: APOD_HUMAN

NCBI Description

This gene encodes a component of high density lipoprotein that has no marked similarity to other apolipoprotein sequences. It has a high degree of homology to plasma retinol-binding protein and other members of the alpha 2 microglobulin protein superfamily of carrier proteins, also known as lipocalins. This glycoprotein is closely associated with the enzyme lecithin:cholesterol acyltransferase - an enzyme involved in lipoprotein metabolism. [provided by RefSeq, Aug 2008]

Uniprot Description

APOD: APOD occurs in the macromolecular complex with lecithin- cholesterol acyltransferase. It is probably involved in the transport and binding of bilin. Appears to be able to transport a variety of ligands in a number of different contexts. Belongs to the calycin superfamily. Lipocalin family.

Protein type: Lipid-binding; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 3q29

Cellular Component: extracellular space; cell soma; perinuclear region of cytoplasm; endoplasmic reticulum; dendrite; extracellular region

Molecular Function: lipid transporter activity; protein binding; cholesterol binding

Biological Process: response to drug; response to reactive oxygen species; tissue regeneration; negative regulation of smooth muscle cell proliferation; negative regulation of focal adhesion formation; glucose metabolic process; negative regulation of protein import into nucleus; response to axon injury; angiogenesis; brain development; lipid metabolic process; lipid transport; axon regeneration in the peripheral nervous system; aging