Apolipoprotein A-II/APOA2 Recombinant Protein | APOA2 recombinant protein

Apolipoprotein A-II/APOA2, Human Recombinant

Cat. Num. AAA8400007

• Gene Names: APOA2; apoAII; Apo-AII; ApoA-II
• Purity: >90% as determined by SDS-PAGE.
• Synonyms: Apolipoprotein A-II/APOA2; Human Recombinant; Apolipoprotein A-II; APOA2; Apo-AII; ApoA-II; Apolipoprotein A2; APOA2 recombinant protein

• Host: E Coli
• Purity/Purification: >90% as determined by SDS-PAGE.
• Form/Format: Lyophilized powder. Lyophilized from 0.22um filtered solution in PBS, pH7.4. Normally trehalose is added as protectant before lyophilization.
• Sequence: aaAla19-Gln100

• Gene Source: Human
• Endotoxin: Less than 1.0 EU per ug by the LAL method.
• Reconstitution Instruction: Reconstitute in sterile deionized water to a concentration of 100 ug/ml. Do not vortex. It is recommended to store at store at -20 degree C.
• Tag Note: This protein carries a polyhistidine tag at the C-terminus.
• Preparation and Storage: Store at -20 degree C; Centrifuge the vial prior to opening.; Shelf life: ~12 months

SDS-Page

Related Product Information for APOA2 recombinant protein

Apolipoprotein A-II (APO-A2) stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. It is produced by the liver and is involved in cholesteryl ester formation and cholesterol transport from tissues to the liver. Recent studies have established the interaction between APOA2 -256T>C polymorphism and dietary saturated fatty acids intake in relation to obesity on healthy individuals. Significant interaction between APOA2-saturated fatty acids intake and body mass index (BMI). The result of this study confirmed the interaction between APOA2 -256T>C polymorphism and SFAs intake with BMI in type 2 diabetic patients. Regulates HDL metabolism

Product Categories/Family for APOA2 recombinant protein

Proteins; Enzymes; Proteins & Enzymes (A-Z); Apolipoproteins; Diabetes; Obesity & Metabolic Syndrome; Lipids Metabolism; Apolipoproteins; Cytokines; Growth Factors & Hormones; Human cell expressed recombinant proteins

NCBI and Uniprot Product Information

• NCBI GI #: 4502149
• NCBI GeneID: 336
• NCBI Accession #: NP_001634.1
• NCBI GenBank Nucleotide #: NM_001643.1
• UniProt Accession #: P02652; B2R524
• Molecular Weight: 11,175 Da
• NCBI Official Full Name: apolipoprotein A-II preproprotein
• NCBI Official Synonym Full Names: apolipoprotein A-II
• NCBI Official Symbol: APOA2
• NCBI Official Synonym Symbols: apoAII; Apo-AII; ApoA-II
• NCBI Protein Information: apolipoprotein A-II; apolipoprotein A2
• UniProt Protein Name: Apolipoprotein A-II
• Protein Family: Apolipoprotein
• UniProt Gene Name: APOA2
• UniProt Synonym Gene Names: Apo-AII; ApoA-II
• UniProt Entry Name: APOA2_HUMAN

NCBI Description

This gene encodes apolipoprotein (apo-) A-II, which is the second most abundant protein of the high density lipoprotein particles. The protein is found in plasma as a monomer, homodimer, or heterodimer with apolipoprotein D. Defects in this gene may result in apolipoprotein A-II deficiency or hypercholesterolemia. [provided by RefSeq, Jul 2008]

Uniprot Description

APOA2: May stabilize HDL (high density lipoprotein) structure by its association with lipids, and affect the HDL metabolism. Belongs to the apolipoprotein A2 family.

Protein type: Endoplasmic reticulum; Secreted, signal peptide; Secreted; Lipid-binding

Chromosomal Location of Human Ortholog: 1q23.3

Cellular Component: chylomicron; endoplasmic reticulum lumen; early endosome; extracellular region; cytosol

Molecular Function: lipid transporter activity; protein binding; protein homodimerization activity; lipase inhibitor activity; protein heterodimerization activity; cholesterol transporter activity; cholesterol binding; phospholipid binding; phosphatidylcholine binding; lipid binding; high-density lipoprotein binding; apolipoprotein receptor binding

Biological Process: positive regulation of catalytic activity; phototransduction, visible light; viral reproduction; protein folding; negative regulation of cholesterol transport; response to glucocorticoid stimulus; regulation of protein stability; diacylglycerol catabolic process; positive regulation of lipid catabolic process; cellular lipid metabolic process; negative regulation of lipase activity; negative regulation of lipid catabolic process; regulation of cholesterol absorption; phospholipid efflux; response to glucose stimulus; retinoid metabolic process; response to drug; cholesterol metabolic process; organ regeneration; protein amino acid oxidation; phospholipid catabolic process; positive regulation of interleukin-8 biosynthetic process; cholesterol efflux; lipoprotein metabolic process; negative regulation of cytokine secretion during immune response; cholesterol homeostasis; triacylglycerol metabolic process; reverse cholesterol transport; response to estrogen stimulus; peptidyl-methionine modification; phosphatidylcholine biosynthetic process; acute inflammatory response

Disease: Hypercholesterolemia, Familial