Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using TUSC2 antibody. Blue: DAPI for nuclear staining.)
Rabbit TUSC2 Polyclonal Antibody | anti-TUSC2 antibody
TUSC2 Polyclonal Antibody
Reactivity
Human, Mouse, Rat
Applications
Western Blot, Immunohistochemistry, Immunofluorescence
Purity
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Synonyms
TUSC2; Polyclonal Antibody; TUSC2 Polyclonal Antibody; C3orf11; Fus-1 protein; FUS1; Fusion 1 protein; LGCC; PAP; PDAP2; PDGFA associated protein 2; PDGFA-associated protein 2; Tumor suppressor candidate 2; TUSC 2; Tusc2; anti-TUSC2 antibody
Host
Rabbit
Reactivity
Human, Mouse, Rat
Clonality
Polyclonal
Isotype
IgG
Specificity
TUSC2 polyclonal antibody detects endogenous levels of TUSC2 protein.
Purity/Purification
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is >95% (by SDS-PAGE).
Form/Format
Rabbit IgG, 1mg/ml in PBS with 0.02% sodium azide, 50% glycerol, pH7.2
Sequence Length
110
Applicable Applications for anti-TUSC2 antibody
Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF)
Application Notes
WB: 1:500-1:2000
IHC: 1:50-1:200
IF: 1:50-1:200
IHC: 1:50-1:200
IF: 1:50-1:200
Immunogen
Recombinant full length Human TUSC2.
Preparation and Storage
Store at 4 degree C short term.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Aliquot and store at -20 degree C long term.
Avoid freeze-thaw cycles.
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using TUSC2 antibody. Blue: DAPI for nuclear staining.)
Immunofluorescence (IF)
(Immunofluorescence analysis of U2OS cell using TUSC2 antibody. Blue: DAPI for nuclear staining.)
Related Product Information for anti-TUSC2 antibody
TUSC2 (tumor suppressor candidate 2), also known as FUS1, LGCC or PDAP2, is a 110 amino acid protein that is expressed at high levels in kidney, pancreas, lung, heart and skeletal muscle where it is thought to function as a tumor suppressor. More specifically, TUSC2 inhibits invasive colony formation by inducing G1 cell cycle arrest and ultimately causing apoptosis, thereby preventing tumor growth. The gene encoding TUSC2 maps to human chromosome 3, which houses over 1, 100 genes, including a chemokine receptor (CKR) gene cluster and a variety of human cancer-related gene loci. Key tumor suppressing genes on chromosome 3 include those that encode the apoptosis mediator RASSF1, the cell migration regulator HYAL1 and the angiogenesis suppressor SEMA3B.
NCBI and Uniprot Product Information
NCBI GI #
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
~ 12kDa
NCBI Official Full Name
tumor suppressor candidate 2
UniProt Protein Name
Tumor suppressor candidate 2
Protein Family
UniProt Gene Name
TUSC2
UniProt Synonym Gene Names
C3orf11; FUS1; LGCC; PDAP2; Fus-1 protein
UniProt Entry Name
TUSC2_HUMAN
Uniprot Description
TUSC2: May function as a tumor suppressor, inhibiting colony formation, causing G1 arrest and ultimately inducing apoptosis in homozygous 3p21.3 120-kb region-deficient cells. Belongs to the TUSC2 family.
Protein type: Tumor suppressor
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: mitochondrion
Biological Process: interleukin-15 production; cell proliferation; negative regulation of interleukin-17 production; regulation of mitochondrial membrane potential; cell-cell signaling; natural killer cell differentiation; response to defense-related host reactive oxygen species production; cell maturation; inflammatory response; cell cycle; phagocytosis; positive regulation of interleukin-10 production
Similar Products
Product Notes
The TUSC2 tusc2 (Catalog #AAA3011933) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. The TUSC2 Polyclonal Antibody reacts with Human, Mouse, Rat and may cross-react with other species as described in the data sheet. AAA Biotech's TUSC2 can be used in a range of immunoassay formats including, but not limited to, Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF). WB: 1:500-1:2000 IHC: 1:50-1:200 IF: 1:50-1:200. Researchers should empirically determine the suitability of the TUSC2 tusc2 for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "TUSC2, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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