Gamma-secretase subunit aph-1 (aph-1) Recombinant Protein | aph-1 recombinant protein
Recombinant Gamma-secretase subunit aph-1 (aph-1)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Gamma-secretase subunit aph-1 (aph-1); Recombinant Gamma-secretase subunit aph-1 (aph-1); Gamma-secretase subunit aph-1; Anterior-pharynx-defective protein 1 Presenilin enhancer protein 1; aph-1 recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
1-308
Sequence
MGYLLTIACYIASFSPSIALFCSFIAHDPVRIILFFLGSFFWLVSLLFSSLAWLGLSTVLPDTFLLSLTVCIIAQELSRVAYFMLLKKAQRGLNKITRQGQISVAPGVSDLHNARHMLALVCGLGMGVISALFYTMNAFAIFSGPGTIGLPNALKTGEIDTNRAGKYLPLCYTLSAILLTLFHVTWTIMVWDSCHKIGRIPSAFVPGAAAVVSHLLVTFLSSLNSRGFHVLVFAVQFLILLICIAYCNVIMGGTISSFVNGIGQSITDAVTLKQVRTLIEERKLRTQRQSVPDEPMTERAGTSNTVNA
Sequence Length
308
Species
Caenorhabditis elegans
Preparation and Storage
Store at -20 degree C. For extended storage, store at -20 or -80 degree C.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
33,548 Da
NCBI Official Full Name
Protein APH-1
NCBI Official Symbol
aph-1
NCBI Protein Information
Protein APH-1
UniProt Protein Name
Gamma-secretase subunit aph-1
UniProt Gene Name
aph-1
UniProt Synonym Gene Names
pen-1
UniProt Entry Name
APH1_CAEEL
Uniprot Description
Function: Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors (lin-12 or glp-1). It may represent a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Required for the localization of aph-2. Ref.1 Ref.2
Subunit structure: Component of the gamma-secretase complex, a complex probably composed of the presenilin homodimer (sel-12, hop-1 or spe-4), nicastrin (aph-2), aph-1 and pen-2
Probable.
Subcellular location: Membrane; Multi-pass membrane protein
Potential.
Sequence similarities: Belongs to the APH-1 family.
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Product Notes
The aph-1 aph-1 (Catalog #AAA1171193) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 1-308. The amino acid sequence is listed below: MGYLLTIACY IASFSPSIAL FCSFIAHDPV RIILFFLGSF FWLVSLLFSS LAWLGLSTVL PDTFLLSLTV CIIAQELSRV AYFMLLKKAQ RGLNKITRQG QISVAPGVSD LHNARHMLAL VCGLGMGVIS ALFYTMNAFA IFSGPGTIGL PNALKTGEID TNRAGKYLPL CYTLSAILLT LFHVTWTIMV WDSCHKIGRI PSAFVPGAAA VVSHLLVTFL SSLNSRGFHV LVFAVQFLIL LICIAYCNVI MGGTISSFVN GIGQSITDAV TLKQVRTLIE ERKLRTQRQS VPDEPMTERA GTSNTVNA. It is sometimes possible for the material contained within the vial of "Gamma-secretase subunit aph-1 (aph-1), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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