Serum amyloid P component / APCS / SAP Recombinant Protein | SAP recombinant protein
Recombinant Mouse Serum amyloid P component / APCS / SAP Protein (His tag)
Gene Names
Apcs; Sap
Purity
> 90 % as determined by SDS-PAGE
Synonyms
Serum amyloid P component / APCS / SAP; Recombinant Mouse Serum amyloid P component / APCS / SAP Protein (His tag); Ptx2; Sap; Apcs; SAP recombinant protein
Host
Human Cells
Purity/Purification
> 90 % as determined by SDS-PAGE
Form/Format
Lyophilized from sterile PBS, pH 7.4
Sequence Length
224
Application Notes
The secreted recombinant mouse APCS consists of 215 amino acids and has a calculated molecular mass of 25.3 kDa. As a result of glycosylation, the recombinant protein migrates as an approximately 28 kDa protein in SDS-PAGE under reducing conditions.
Predicted N Terminal
Gln 21
Endotoxin
< 1.0 EU per mug of the protein as determined by the LAL method
Preparation and Storage
Samples are stable for up to twelve months from date of receipt at -70 degree C
SDS-PAGE
Related Product Information for SAP recombinant protein
Background: Serum amyloid P component (SAP) is the identical serum form of amyloid P component (AP), a highly preserved plasma protein named for its ubiquitous presence in amyloid deposits. As a normal plasma protein first identified as the pentagonal constituent of in vivo pathological deposits called "amyloid". Serum amyloid P component represents another member of the pentraxin family, a highly conserved group of molecules that may play a role in innate immunity. SAP is a key negative regulator for innate immune responses to DNA and may be partly responsible for the insufficient immune responses after DNA vaccinations in humans. SAP suppression may be a novel strategy for improving efficacy of human DNA vaccines and requires further clinical investigations.
Description: A DNA sequence encoding the mouse APCS (NP_035448.2) (Met 1-Glu 224) precursor was expressed with a C-terminal polyhistidine tag.
Description: A DNA sequence encoding the mouse APCS (NP_035448.2) (Met 1-Glu 224) precursor was expressed with a C-terminal polyhistidine tag.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
UniProt Accession #
Molecular Weight
26,247 Da
NCBI Official Full Name
serum amyloid P-component
NCBI Official Synonym Full Names
serum amyloid P-component
NCBI Official Symbol
Apcs
NCBI Official Synonym Symbols
Sap
NCBI Protein Information
serum amyloid P-component
UniProt Protein Name
Serum amyloid P-component
Protein Family
UniProt Gene Name
Apcs
UniProt Synonym Gene Names
Ptx2; Sap; SAP
Uniprot Description
APCS: Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. May also function as a calcium-dependent lectin. SAP is a precursor of amyloid component P which is found in basement membrane and associated with amyloid deposits. Belongs to the pentaxin family.
Protein type: Chaperone; Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 1 H3|1 80.33 cM
Cellular Component: extracellular matrix; extracellular space; nucleus; protein complex
Molecular Function: calcium ion binding; complement component C1q binding; virion binding
Biological Process: innate immune response; negative regulation of monocyte differentiation; negative regulation of viral reproduction; negative regulation of virion penetration into host cell; protein complex assembly
