Acyloxyacyl hydrolase (AOAH) Recombinant Protein | AOAH recombinant protein
Recombinant Human Acyloxyacyl hydrolase (AOAH)
Purity
Greater or equal to 85% purity as determined by SDS-PAGE.
Synonyms
Acyloxyacyl hydrolase (AOAH); Recombinant Human Acyloxyacyl hydrolase (AOAH); AOAH recombinant protein
Host
E Coli or Yeast or Baculovirus or Mammalian Cell
Purity/Purification
Greater or equal to 85% purity as determined by SDS-PAGE.
Form/Format
Lyophilized or liquid (Format to be determined during the manufacturing process)
Sequence Positions
35-575aa; Full Length of Mature Protein
Sequence
LSNGHTCVGCVLVVSVIEQLAQVHNSTVQASMERLCSYLPEKLFLKTTCYLVIDKFGSDIIKLLSADMNADVVCHTLEFCKQNTGQPLCHLYPLPKETWKFTLQKARQIVKKSPILKYSRSGSDICSLPVLAKICQKIKLAMEQSVPFKDVDSDKYSVFPTLRGYHWRGRDCNDSDESVYPGRRPNNWDVHQDSNCNGIWGVDPKDGVPYEKKFCEGSQPRGIILLGDSAGAHFHISPEWITASQMSLNSFINLPTALTNELDWPQLSGATGFLDSTVGIKEKSIYLRLWKRNHCNHRDYQNISRNGASSRNLKKFIESLSRNKVLDYPAIVIYAMIGNDVCSGKSDPVPAMTTPEKLYSNVMQTLKHLNSHLPNGSHVILYGLPDGTFLWDNLHNRYHPLGQLNKDMTYAQLYSFLNCLQVSPCHGWMSSNKTLRTLTSERAEQLSNTLKKIAASEKFTNFNLFYMDFAFHEIIQEWQKRGGQPWQLIEPVDGFHPNEVALLLLADHFWKKVQLQWPQILGKENPFNPQIKQVFGDQGGH
Species
Human
Preparation and Storage
Store at -20 degrees C. For long-term storage, store at -20 degrees C or -80 degrees C. Store working aliquots at 4 degrees C for up to one week. Repeated freezing and thawing is not recommended.
Related Product Information for AOAH recombinant protein
Acyloxyacyl hydrolase (AOAH) is a 2-subunit lipase which selectively hydrolyzes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial endotoxins. AOAH may modulate host inflammatory responses to gram-negative bacterial invasion. The 2 subunits are encoded by a single mRNA.
NCBI and Uniprot Product Information
NCBI GI #
NCBI GeneID
NCBI Accession #
NCBI GenBank Nucleotide #
Molecular Weight
61,647 Da
NCBI Official Full Name
acyloxyacyl hydrolase isoform 2 preproprotein
NCBI Official Synonym Full Names
acyloxyacyl hydrolase
NCBI Official Symbol
AOAH
NCBI Protein Information
acyloxyacyl hydrolase
UniProt Protein Name
Acyloxyacyl hydrolase
Protein Family
UniProt Gene Name
AOAH
NCBI Description
This locus encodes both the light and heavy subunits of acyloxyacyl hydrolase. The encoded enzyme catalyzes the hydrolysis of acyloxylacyl-linked fatty acyl chains from bacterial lipopolysaccharides, effectively detoxifying these molecules. The encoded protein may play a role in modulating host inflammatory response to gram-negative bacteria. Alternatively spliced transcript variants have been described.[provided by RefSeq, Apr 2010]
Uniprot Description
Removes the secondary (acyloxyacyl-linked) fatty acyl chains from the lipid A region of bacterial lipopolysaccharides (PubMed:1883828, PubMed:8089145). By breaking down LPS, terminates the host response to bacterial infection and prevents prolonged and damaging inflammatory responses (). In peritoneal macrophages, seems to be important for recovery from a state of immune tolerance following infection by Gram-negative bacteria ().
Research Articles on AOAH
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Product Notes
The AOAH aoah (Catalog #AAA958374) is a Recombinant Protein produced from E Coli or Yeast or Baculovirus or Mammalian Cell and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 35-575aa; Full Length of Mature Protein. The amino acid sequence is listed below: LSNGHTCVGC VLVVSVIEQL AQVHNSTVQA SMERLCSYLP EKLFLKTTCY LVIDKFGSDI IKLLSADMNA DVVCHTLEFC KQNTGQPLCH LYPLPKETWK FTLQKARQIV KKSPILKYSR SGSDICSLPV LAKICQKIKL AMEQSVPFKD VDSDKYSVFP TLRGYHWRGR DCNDSDESVY PGRRPNNWDV HQDSNCNGIW GVDPKDGVPY EKKFCEGSQP RGIILLGDSA GAHFHISPEW ITASQMSLNS FINLPTALTN ELDWPQLSGA TGFLDSTVGI KEKSIYLRLW KRNHCNHRDY QNISRNGASS RNLKKFIESL SRNKVLDYPA IVIYAMIGND VCSGKSDPVP AMTTPEKLYS NVMQTLKHLN SHLPNGSHVI LYGLPDGTFL WDNLHNRYHP LGQLNKDMTY AQLYSFLNCL QVSPCHGWMS SNKTLRTLTS ERAEQLSNTL KKIAASEKFT NFNLFYMDFA FHEIIQEWQK RGGQPWQLIE PVDGFHPNEV ALLLLADHFW KKVQLQWPQI LGKENPFNPQ IKQVFGDQGG H . It is sometimes possible for the material contained within the vial of "Acyloxyacyl hydrolase (AOAH), Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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