Annexin A6 Recombinant Protein | Anxa6 recombinant protein

Annexin A6, Recombinant, Human (ANXA6, ANX6, CBP68)

Cat. Num. AAA637427

• Gene Names: Anxa6; Anx6; CPB-II
• Applications: Western Blot
• Purity: >90% by SDS-PAGE under reducingconditons and visualized by coomassie blue stain
• Synonyms: Annexin A6; Recombinant; Human (ANXA6; ANX6; CBP68); Anxa6 recombinant protein

• Host: E Coli
• Purity/Purification: >90% by SDS-PAGE under reducingconditons and visualized by coomassie blue stain
• Form/Format: Supplied as a liquid 20mM Tris-HCl buffer, pH8.0, 10% glycerol, 0.1M NaCl.
• Concentration: 0.5mg/ml (varies by lot)
• Sequence: MGSSHHHHHH SSGLVPRGSH MAKPAQGAKY RGSIHDFPGF DPNQDAEALY TAMKGFGSDK EAILDIITSR SNRQRQEVCQ SYKSLYGKDL IADLKYELTG KFERLIVGLM RPPAYCDAKE IKDAISGIGT DEKCLIEILA SRTNEQMHQL VAAYKDAYER DLEADIIGDT SGHFQKMLVV LLQGTREEDD VVSEDLVQQD VQDLYEAGEL KWGTDEAQFI YILGNRSKQH LRLVFDEYLK TTGKPIEASI RGELSGDFEK LMLAVVKCIR STPEYFAERL FKAMKGLGTR DNTLIRIMVS RSELDMLDIR EIFRTKYEKS LYSMIKNDTS GEYKKTLLKL SGGDDDAAGQ FFPEAAQVAY QMWELSAVAR VELKGTVRPA NDFNPDADAK ALRKAMKGLG TDEDTIIDII THRSNVQRQQ IRQTFKSHFG RDLMTDLKSE ISGDLARLIL GLMMPPAHYD AKQLKKAMEG AGTDEKALIE ILATRTNAEI RAINEAYKED YHKSLEDALS SDTSGHFRRI LISLATGHRE EGGENLDQAR EDAQVAAEIL EIADTPSGDK TSLETRFMTI LCTRSYPHLR RVFQEFIKMT NYDVEHTIKK EMSGDVRDAF VAIVQSVKNK PLFFADKLYK SMKGAGTDEK TLTRIMVSRS EIDLLNIRRE FIEKYDKSLH QAIEGDTSGD FLKALLALCG GED

• Applicable Applications for Anxa6 recombinant protein: Western Blot (WB)
• Application Notes: Suitable for use in Western Blot.
• Endotoxin Level: 1EU/1ug (LAL).
• Preparation and Storage: May be stored at 4 degree C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20 degree C. Aliquots are stable for at least 6 months. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.

SDS-Page

(15% SDS-PAGE using MBS637427 (3ug))

Related Product Information for Anxa6 recombinant protein

Annexin A6 belongs to a family of calcium-dependent membrane and phospholipid binding proteins. Although their functions are still not clearly defined, several members of the annexin family have been implicated in membrane-related events along exocytotic and endocytotic pathways. Annexin6 has been implicated in mediating the endosome aggregation and vesicle fusion in secreting epithelia during exocytosis.

Recombinant Annexin A6 protein was expressed in E.coli and purified by using conventional chromatography techniques.

Product Categories/Family for Anxa6 recombinant protein

Molecular Biology; MB-Annexin

NCBI and Uniprot Product Information

• NCBI GI #: 130502086
• NCBI GeneID: 79125
• NCBI Accession #: NP_077070.2
• NCBI GenBank Nucleotide #: NM_024156.2
• UniProt Accession #: P48037
• Molecular Weight: 78kD
• NCBI Official Full Name: annexin A6
• NCBI Official Synonym Full Names: annexin A6
• NCBI Official Symbol: Anxa6
• NCBI Official Synonym Symbols: Anx6; CPB-II
• NCBI Protein Information: annexin A6; CBP 65/67; annexin-6; annexin VI; lipocortin VI; calphobindin-II; chromobindin-20; 67 kDa calelectrin; calcium-binding protein 65/67; calcium-binding protein CATA 65/67
• UniProt Protein Name: Annexin A6
• Protein Family: Annexin
• UniProt Gene Name: Anxa6
• UniProt Synonym Gene Names: Anx6; CBP 65/67
• UniProt Entry Name: ANXA6_RAT

NCBI Description

Ca(2+)-sensitive phospholipid-binding protein that binds CRHSP-28 [RGD, Feb 2006]

Uniprot Description

ANXA6: a calcium/phospholipid-binding protein that may associate with CD21. May regulate the release of Ca(2+) from intracellular stores. Phosphorylated in response to growth factor stimulation. Annexins are a family of structurally related proteins whose common property is calcium-dependent binding to phospholipids. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion.

Protein type: Calcium-binding; Motility/polarity/chemotaxis; Lipid-binding

Cellular Component: protein complex; focal adhesion; membrane; late endosome membrane; lysosomal membrane; perinuclear region of cytoplasm; apical plasma membrane; cytoplasm; melanosome

Molecular Function: protein homodimerization activity; GTP binding; calcium-dependent phospholipid binding; cholesterol binding; calcium ion binding; ligand-gated ion channel activity; lipid binding; calcium-dependent protein binding

Biological Process: secretion; regulation of muscle contraction; calcium ion transport; protein homooligomerization