Anthrax toxin receptor 2 Recombinant Protein | ANTXR2 recombinant protein
Anthrax toxin receptor 2
Repeated freezing and thawing is not recommended. Store working aliquots at 4 degree C for up to one week.
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a receptor for anthrax toxin. The protein binds to collagen IV and laminin, suggesting that it may be involved in extracellular matrix adhesion. Mutations in this gene cause juvenile hyaline fibromatosis and infantile systemic hyalinosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]
Uniprot Description
ANTXR2: Necessary for cellular interactions with laminin and the extracellular matrix. Defects in ANTXR2 are the cause of infantile systemic hyalinosis (ISH). This autosomal recessive syndrome is similar to JHF, but has an earlier onset and a more severe course. Symptoms appear at birth or within the first months of life, with painful, swollen joint contractures, osteopenia, osteoporosis and livid red hyperpigmentation over bony prominences. Patients develop multiple subcutaneous skin tumors and gingival hypertrophy. Hyaline deposits in multiple organs, recurrent infections and intractable diarrhea often lead to death within the first 2 years of life. Surviving children may suffer from severely reduced mobility due to joint contractures. Defects in ANTXR2 are the cause of juvenile hyaline fibromatosis (JHF). JHF is an autosomal recessive syndrome that is similar to ISH but takes a milder course. It is characterized by hyaline deposition in the dermis, multiple subcutaneous skin tumors and gingival hypertrophy, followed by progressive joint contractions, osteopenia and osteoporosis that may lead to a severe limitation of mobility. Belongs to the ATR family. 4 isoforms of the human protein are produced by alternative splicing.
Protein type: Receptor, misc.; Membrane protein, integral
Chromosomal Location of Human Ortholog: 4q21.21
Cellular Component: endosome membrane; plasma membrane
Molecular Function: protein binding
Disease: Hyaline Fibromatosis Syndrome
Research Articles on ANTXR2
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Product Notes
The ANTXR2 antxr2 (Catalog #AAA7042110) is a Recombinant Protein produced from Cell Free Expression and is intended for research purposes only. The product is available for immediate purchase. The immunogen sequence is 34-489aa; full length protein. The amino acid sequence is listed below: QEQPSCRRAF DLYFVLDKSG SVANNWIEIY NFVQQLAERF VSPEMRLSFI VFSSQATIIL PLTGDRGKIS KGLEDLKRVS PVGETYIHEG LKLANEQIQK AGGLKTSSII IALTDGKLDG LVPSYAEKEA KISRSLGASV YCVGVLDFEQ AQLERIADSK EQVFPVKGGF QALKGIINSI LAQSCTEILE LQPSSVCVGE EFQIVLSGRG FMLGSRNGSV LCTYTVNETY TTSVKPVSVQ LNSMLCPAPI LNKAGETLDV SVSFNGGKSV ISGSLIVTAT ECSNGIAAII VILVLLLLLG IGLMWWFWPL CCKVVIKDPP PPPAPAPKEE EEEPLPTKKW PTVDASYYGG RGVGGIKRME VRWGDKGSTE EGARLEKAKN AVVKIPEETE EPIRPRPPRP KPTHQPPQTK WYTPIKGRLD ALWALLRRQY DRVSLMRPQE GDEVCIWECI EKELTA. It is sometimes possible for the material contained within the vial of "Anthrax toxin receptor 2, Recombinant Protein" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
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