Ro/SS-A Antigen
Ro/SS-A Antigen (SSA1, Sjogren Syndrome Antigen A1, 52kD Ribonucleoprotein Autoantigen SS-A/Ro, RO52, RNF81, Tripartite Motif Protein 21, TRIM21)
Applications
ELISA
Purity
Affinity Purified90% pure (SDS-PAGE)
Synonyms
Ro/SS-A Antigen; Ro/SS-A Antigen (SSA1; Sjogren Syndrome Antigen A1; 52kD Ribonucleoprotein Autoantigen SS-A/Ro; RO52; RNF81; Tripartite Motif Protein 21; TRIM21); Ro/SS-A Antigen antigen
Purity/Purification
Affinity Purified
90% pure (SDS-PAGE)
90% pure (SDS-PAGE)
Form/Format
Supplied as a liquid in 20mM HEPES-NaOH, pH 7.5, 0.32M sodium chloride, 2mM MgCl2, 0.2mM DTT, 0.1mM PMSF, 0.1% preservative, bromo-nitro-dioxane/methylisothiazoline, 20% glycerol.
Applicable Applications for Ro/SS-A Antigen antigen
ELISA (EL/EIA)
Application Notes
Suitable for use in ELISA.
Dilution: ELISA: 0.5-1ug/ml
Dilution: ELISA: 0.5-1ug/ml
Preparation and Storage
Aliquot to avoid repeated freezing and thawing and freeze at -70 degree C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Aliquots are stable for at least 6 months.
Related Product Information for Ro/SS-A Antigen antigen
The (Ro) SS-A antigen is comprised or an acidic 60kD protein that may also be associated with a RNA ranging in size from 80 to 112 bases. The antigenic activity of the (Ro) SS-A antigen appears to be independent of the RNA since the precipitin activity remains after treatment with RNase or separation from the RNA. Anti-(Ro) SS-A autoantibodies were described originally as precipitating autoantibodies in sera of Sjogren's Syndrome and Systemic Lupus Erythematosus patients. The presence of autoantibodies against the (Ro)SS-A antigen may be used as an aid. Elevated levels of Anti-(Ro) SS-A have been detected in as high as 96% of Sjogren's Syndrome patients, 49% of patients with Systemic Lupus Erythematosus, 83% of mothers of infants with isolated complete congenital heartblock or Neonatal Lupus Dermatitis, and over 75% of patients with Subacute Cutaneous Lupus. Recently, a strong correlation between low positive levels of Anti-(Ro) SS-A and subdinical dry eyes or mouth was found in a substantial portion of an elderly population. In addition, it has been shown that 70% of patients with (Ro) SS-A precipitating antibodies also have rheumatoid factor. The titer of rheumatoid factor and the concentration of Anti-(Ro) SSA have been closely correlated in Primary Sjogren's Syndrome. Recent developments in ELISA methodology have increased the sensitivity and the ability of to quantitate patient antibody titers.
Product Categories/Family for Ro/SS-A Antigen antigen
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Product Notes
The Ro/SS-An Antigen (Catalog #AAA651597) is an Antigen and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's Ro/SS-An Antigen can be used in a range of immunoassay formats including, but not limited to, ELISA (EL/EIA). Suitable for use in ELISA. Dilution: ELISA: 0.5-1ug/ml. Researchers should empirically determine the suitability of the Ro/SS-An Antigen for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "Ro/SS-A Antigen, Antigen" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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