Testing Data #1
(Staining of formalin fixed, paraffin embedded human colon surface epithelium with Rabbut anti Human CD136 (MBS222802))
Rabbit CD136 Polyclonal Antibody | anti-CD136 antibody
RABBIT ANTI HUMAN CD136
CD136 is a disulfide-linked 180kD heterodimer composed of a 40kD alpha chain and a 150kD beta chain, and is mainly expressed in cells of epithelial origin. In immune cells CD136 expression is restricted to certain types of tissue macrophages, and its activation is critical in modulating macrophage activities and preventing an excessive inflammatory response. CD136 is also required for embryonic development.
CD136 expression is significantly altered in several primary human cancers including those of the breast and colon.
Purified IgG - liquid
Histology Positive Control Tissue
Shelf Life: 18 months from date of despatch.
Testing Data #1
(Staining of formalin fixed, paraffin embedded human colon surface epithelium with Rabbut anti Human CD136 (MBS222802))
Testing Data #1
(Staining of formalin fixed, paraffin embedded human colon surface epithelium with Rabbut anti Human CD136 (MBS222802))
NCBI and Uniprot Product Information
NCBI Description
This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternatively spliced transcript variants encoding different isoforms with different structural and biochemical properties have been described (PMID:8816464). [provided by RefSeq, Oct 2011]
Uniprot Description
Ron: a receptor tyrosine kinase of the Met family. Receptor for macrophage stimulating protein. Can be desensitized by c-Cbl and its binding partner Grb2. Overexpression of wild-type RON causes the formation of lung tumors. Two alternatively spliced isoforms have been described.
Protein type: Membrane protein, integral; Protein kinase, TK; EC 2.7.10.1; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; Met family
Chromosomal Location of Human Ortholog: 3p21.3
Cellular Component: cell surface; integral to plasma membrane; stress fiber
Molecular Function: macrophage colony stimulating factor receptor activity; protein binding; enzyme binding; ATP binding
Biological Process: positive regulation of MAP kinase activity; positive regulation of protein kinase B signaling cascade; peptidyl-tyrosine phosphorylation; single fertilization; multicellular organismal development; response to virus; positive regulation of cell proliferation; innate immune response; defense response; cell motility; signal transduction; transmembrane receptor protein tyrosine kinase signaling pathway
Research Articles on CD136
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Product Notes
The CD136 mst1r (Catalog #AAA222802) is an Antibody produced from Rabbit and is intended for research purposes only. The product is available for immediate purchase. AAA Biotech's CD136 can be used in a range of immunoassay formats including, but not limited to, Immunohistology Paraffin*. Immunohistology - Paraffin: Maximum Dilution: 5ug/ml; Application Note: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer pH 6.0 is recommended for this purpose. Researchers should empirically determine the suitability of the CD136 mst1r for an application not listed in the data sheet. Researchers commonly develop new applications and it is an integral, important part of the investigative research process. It is sometimes possible for the material contained within the vial of "CD136, Polyclonal Antibody" to become dispersed throughout the inside of the vial, particularly around the seal of said vial, during shipment and storage. We always suggest centrifuging these vials to consolidate all of the liquid away from the lid and to the bottom of the vial prior to opening. Please be advised that certain products may require dry ice for shipping and that, if this is the case, an additional dry ice fee may also be required.Precautions
All products in the AAA Biotech catalog are strictly for research-use only, and are absolutely not suitable for use in any sort of medical, therapeutic, prophylactic, in-vivo, or diagnostic capacity. By purchasing a product from AAA Biotech, you are explicitly certifying that said products will be properly tested and used in line with industry standard. AAA Biotech and its authorized distribution partners reserve the right to refuse to fulfill any order if we have any indication that a purchaser may be intending to use a product outside of our accepted criteria.Disclaimer
Though we do strive to guarantee the information represented in this datasheet, AAA Biotech cannot be held responsible for any oversights or imprecisions. AAA Biotech reserves the right to adjust any aspect of this datasheet at any time and without notice. It is the responsibility of the customer to inform AAA Biotech of any product performance issues observed or experienced within 30 days of receipt of said product. To see additional details on this or any of our other policies, please see our Terms & Conditions page.Item has been added to Shopping Cart
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